质量水平
方案
99%
表单
solid
mp
70-73 °C (lit.)
溶解性
chloroform: soluble 50 mg/mL, clear to very slightly hazy, faintly yellow
官能团
chloro
nitro
SMILES字符串
[O-][N+](=O)c1ccc(CCl)cc1
InChI
1S/C7H6ClNO2/c8-5-6-1-3-7(4-2-6)9(10)11/h1-4H,5H2
InChI key
KGCNHWXDPDPSBV-UHFFFAOYSA-N
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一般描述
用对硝基苯氯作为谷胱甘肽 S-转移酶 (GST) 的底物测定中国人胎肝中的 GST 。它被 NADPH 还原生成 4-硝基甲苯 。
应用
用对硝基氯化苄不对称合成了 N，N′- 双 （取代）4,13-二氮杂-18-冠-6-醚衍生物。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Skin Corr. 1B
储存分类代码
8A - Combustible corrosive hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
危险化学品
此项目有
S N Moreno et al.
The Journal of biological chemistry, 261(17), 7811-7815 (1986-06-15)
The o-, m-, and p-nitrobenzyl chlorides are reduced aerobically and anaerobically by NADPH and rat hepatic microsomes. Under aerobic conditions, these nitro anion radicals reduce oxygen to superoxide as demonstrated by oxygen consumption and spin trapping of superoxide with 5,5-dimethyl-1-pyrroline
K Datta et al.
Early human development, 37(3), 167-174 (1994-06-01)
Glutathione S-transferase (GST) with activity towards CDNB as a substrate from human intrauterine conceptual tissues (HICT) at 6-10 weeks of gestation was purified approximately 200-fold by GSH coupled Sepharose 4B affinity chromatography. The preparations of affinity purified HICT-GST were used
Shingo Arakawa et al.
Drug metabolism and disposition: the biological fate of chemicals, 40(3), 497-503 (2011-12-16)
We investigated the impact of glutathione transferases Mu 1 (GSTM1)- and glutathione transferase Theta 1 (GSTT1)-null genotypes on hepatic GST activities in humans and compared the results with those of Gstm1- and Gstt1-null mice. In liver with GSTM1/Gstm1-null genotype, GST
P Jemth et al.
Biochemistry, 38(31), 9982-9991 (1999-08-06)
The reaction mechanism of rat glutathione transferase T2-2 has been studied using pre-steady-state and steady-state kinetics. Several parts of the catalytic cycle including binding of substrates, product formation, and product release were investigated. Under saturating conditions, a two-step product release
S V Singh et al.
Experimental eye research, 41(3), 405-413 (1985-09-01)
When rats were orally administered a daily dose of 300 mg kg-1 body weight of 3,5-di-t-butyl-4-hydroxytoluene (BHT) for 4 days, about 90% increase over basal level in total glutathione (GSH) S-transferase activity towards 1-chloro-2,4-dinitrobenzene (CDNB) was observed in ocular lens.
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