161543
5-(4-羟基苯基)-5-苯基乙内酰脲
98%
别名:
4-Hydroxydiphenylhydantoin, p-Hydroxyphenytoin, NSC 156081
方案
98%
表单
solid
mp
>300 °C (lit.)
溶解性
soluble 50 mg/mL, clear, colorless to faintly yellow (DMF:MeOH(2:1))
官能团
phenyl
SMILES字符串
Oc1ccc(cc1)C2(NC(=O)NC2=O)c3ccccc3
InChI
1S/C15H12N2O3/c18-12-8-6-11(7-9-12)15(10-4-2-1-3-5-10)13(19)16-14(20)17-15/h1-9,18H,(H2,16,17,19,20)
InChI key
XEEDURHPFVXALT-UHFFFAOYSA-N
一般描述
5-(4-Hydroxyphenyl)-5-phenylhydantoin is the major metabolite of phenytoin.
应用
5-(4-Hydroxyphenyl)-5-phenylhydantoin was used in enantiomeric separation of chiral pharmaceuticals using a teicoplanin chiral stationary phase by aqueous and non-aqueous packed capillary electrochromatography. It was used as internal standard in determination of phenylbutazone and its metabolite oxyphenbutazone in human plasma by GLC.
Reactant for activation of hydroxylated metabolites of carbamazepine and phenytoin
Used in studies investigating
Transport across the human placenta barrier
Effects on cellular glucose transport
Used in studies investigating
Transport across the human placenta barrier
Effects on cellular glucose transport
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
GLC determination of plasma concentration of phenylbutazone and its metabolite oxyphenbutazone.
K K Midha et al.
Journal of pharmaceutical sciences, 63(8), 1234-1239 (1974-08-01)
Joo-Ho Park et al.
Biotechnology and bioengineering, 78(7), 779-793 (2002-05-10)
We developed a kinetic model that describes a heterogeneous reaction system for the production of D-p-hydroxyphenylglycine from D,L-p-hydroxyphenyl-hydantoin using D-hydantoinase of Bacillus stearothermophilus SD1 and N-carbamoylase of Agrobacterium tumefaciens NRRL B11291. As a biocatalyst, whole cells with separately or co-expressed
Vikas Kumar et al.
Drug metabolism and disposition: the biological fate of chemicals, 34(12), 1966-1975 (2006-09-12)
Drug-drug interactions may cause serious adverse events in the clinical setting, and the cytochromes P450 are the enzyme system most often implicated in these interactions. Cytochrome P450 2C is the second most abundant subfamily of cytochrome P450 enzymes and is
Yu C Kim et al.
Biopharmaceutics & drug disposition, 29(1), 51-61 (2007-11-21)
It has been reported that diabetic patients have an increased risk of developing epileptic convulsions compared with the non-diabetic population, and phenytoin has widely been used for neuralgia in diabetic neuropathy. It has also been reported that in both diabetic
Phenytoin overview--metabolite interference in some immunoassays could be clinically important.
William L Roberts et al.
Archives of pathology & laboratory medicine, 128(7), 734-734 (2004-07-02)
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