162906
2-羟基-5-硝基苄溴
90%
别名:
α-溴-4-硝基邻甲酚, 2-溴甲基-4-硝基苯酚, Koshland I, Koshland 试剂 I
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关于此项目
线性分子式:
HOC6H3(NO2)CH2Br
化学文摘社编号:
分子量:
232.03
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
212-248-9
Beilstein/REAXYS Number:
1868798
MDL number:
Assay:
90%
Form:
solid
InChI key
KFDPCYZHENQOBV-UHFFFAOYSA-N
InChI
1S/C7H6BrNO3/c8-4-5-3-6(9(11)12)1-2-7(5)10/h1-3,10H,4H2
SMILES string
Oc1ccc(cc1CBr)[N+]([O-])=O
assay
90%
form
solid
solubility
chloroform: soluble 25 mg/mL, clear, yellow
functional group
bromo, nitro
storage temp.
2-8°C
General description
2-Hydroxy-5-nitrobenzyl bromide is a protein modifying reagent.
Application
2-Hydroxy-5-nitrobenzyl bromide was used in covalent modification of tryptophan and tryptophan residues in monoclonal immunoglobulin. It was also used as reagent for sulfhydryl modification
Other Notes
含有 2-羟基-5-硝基苯甲醇
signalword
Danger
hcodes
Hazard Classifications
Skin Corr. 1B
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
C Nishimura et al.
European journal of biochemistry, 196(2), 377-384 (1991-03-14)
Oxidation of the Met residues of human interleukin 6 (IL-6) molecule has been performed. Reactivity of Met for the oxidation reaction was found to decrease in the order of Met50, Met118, Met185, Met162, and Met68. Chemical modifications involving oxidation and
T Maruyama et al.
Biochemical pharmacology, 45(5), 1017-1026 (1993-03-09)
The binding of suprofen (SP), a non-steroidal anti-inflammatory drug of the arylpropionic acid class, and its methyl ester derivative (SPM) to human serum albumin (HSA) was studied by dialysis and spectroscopic techniques. In spite of the remarkable differences in the
G Solaini et al.
The Biochemical journal, 327 ( Pt 2), 443-448 (1997-11-14)
Treatment of bovine heart submitochondrial particles with a low concentration of 2-hydroxy-5-nitrobenzyl bromide (HNB), a selective reagent for the Trp residue of the epsilon subunit [Baracca, Barogi, Lenaz and Solaini (1993) Int. J. Biochem. 25, 1269-1275], enhances the ATP hydrolytic
A Baracca et al.
Biochemistry international, 21(6), 1135-1142 (1990-09-01)
The incubation of bovine mitochondrial F1-ATPase with 2-hydroxy-5-nitrobenzyl bromide (HNB), a selective reagent toward tryptophan residues in proteins, produced a concentration dependent inactivation of the enzyme and the covalent binding of 0.88 mol reagent/mol F1. Although HNB is highly specific
A I Korneliuk et al.
Bioorganicheskaia khimiia, 11(5), 605-612 (1985-05-01)
The structural accessibility of tryptophan residues in leucyl-tRNA synthetase from cow mammary gland has been studied using chemical modifications by N-bromosuccinimide and 2-hydroxy-5-nitrobenzyl bromide. The modifications were monitored by UV absorbance and intrinsic fluorescence of the enzyme's tryptophan residues. Under
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