162906
2-羟基-5-硝基苄溴
90%
别名:
α-溴-4-硝基邻甲酚, 2-溴甲基-4-硝基苯酚, Koshland I, Koshland 试剂 I
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关于此项目
线性分子式:
HOC6H3(NO2)CH2Br
化学文摘社编号:
分子量:
232.03
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
212-248-9
Beilstein/REAXYS Number:
1868798
MDL number:
Assay:
90%
Form:
solid
InChI key
KFDPCYZHENQOBV-UHFFFAOYSA-N
InChI
1S/C7H6BrNO3/c8-4-5-3-6(9(11)12)1-2-7(5)10/h1-3,10H,4H2
SMILES string
Oc1ccc(cc1CBr)[N+]([O-])=O
assay
90%
form
solid
solubility
chloroform: soluble 25 mg/mL, clear, yellow
functional group
bromo, nitro
storage temp.
2-8°C
General description
2-Hydroxy-5-nitrobenzyl bromide is a protein modifying reagent.
Application
2-Hydroxy-5-nitrobenzyl bromide was used in covalent modification of tryptophan and tryptophan residues in monoclonal immunoglobulin. It was also used as reagent for sulfhydryl modification
Other Notes
含有 2-羟基-5-硝基苯甲醇
signalword
Danger
hcodes
Hazard Classifications
Skin Corr. 1B
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
C Locht et al.
Proceedings of the National Academy of Sciences of the United States of America, 86(9), 3075-3079 (1989-05-01)
The enzymatic ADP-ribosyltransferase activity associated with the S1 subunit of pertussis toxin is considered to be responsible for its biological effects. Although pertussis toxin has no significant homology to other ADP-ribosylating toxins such as diphtheria toxin and Pseudomonas aeruginosa exotoxin
M Sabés et al.
Journal of biochemical and biophysical methods, 17(1), 17-24 (1988-09-01)
The use of 2-hydroxy-5-nitrobenzyl bromide for the modification of tryptophan residues in integral membrane proteins is exemplified by its application to bacteriorhodopsin from Halobacterium halobium. Complete elimination of the unreacted reagent requires delipidation of the sample with detergents and posterior
A Baracca et al.
The International journal of biochemistry, 25(9), 1269-1275 (1993-09-01)
1. The F1-ATPase from bovine heart mitochondria was shown to chemically react and to absorb 2-hydroxy-5-nitrobenzyl bromide (HNB) with changes in catalytic properties. 2. The treatment of the enzyme with HNB at concentrations below 0.5 mM resulted in an increase
Arunas Silanskas et al.
Biochemistry, 50(14), 2800-2807 (2011-03-18)
Regulation of proteins by light is a new and promising strategy for the external control of biological processes. In this study, we demonstrate the ability to regulate the catalytic activity of the MunI and PvuII restriction endonucleases with light. We
C Nishimura et al.
European journal of biochemistry, 196(2), 377-384 (1991-03-14)
Oxidation of the Met residues of human interleukin 6 (IL-6) molecule has been performed. Reactivity of Met for the oxidation reaction was found to decrease in the order of Met50, Met118, Met185, Met162, and Met68. Chemical modifications involving oxidation and
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