190306
氢化二异丁基铝 溶液
1.0 M in hexanes
别名:
DIBAL, DIBAL-H
表单
liquid
质量水平
反应适用性
reagent type: reductant
浓度
1.0 M in hexanes
密度
0.701 g/mL at 25 °C
SMILES字符串
CC(C)C[AlH]CC(C)C
InChI
1S/2C4H9.Al.H/c2*1-4(2)3;;/h2*4H,1H2,2-3H3;;
InChI key
AZWXAPCAJCYGIA-UHFFFAOYSA-N
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一般描述
二异丁基氢化铝还原剂通常用于将酯还原成醛。
应用
二异丁基氢化铝溶液（1.0M 己烷溶液）可用于合成二异丁基叔丁氧基铝氢化物（PDBBA），一种在硝基存在下将酯类化合物化学选择性转化的新型还原剂。DIBAL-三乙胺络合物可以将 α-羰基烯酮二硫代缩醛还原成饱和酮。
用于Pd催化的仲烷基溴的还原脱溴过程。过苄基化呋喃糖苷的O-脱苄基和开环。方便从 ZrCp2Cl2 和DIBAL-H原位生成 HZrCp2Cl。
警示用语：
Danger
危险分类
Aquatic Chronic 2 - Asp. Tox. 1 - Eye Dam. 1 - Flam. Liq. 2 - Pyr. Liq. 1 - Repr. 2 - Skin Corr. 1B - STOT RE 1 Inhalation - STOT SE 3 - Water-react 1
靶器官
Central nervous system, Nervous system
补充剂危害
储存分类代码
4.2 - Pyrophoric and self-heating hazardous materials
WGK
WGK 3
闪点(°F)
-9.4 °F - closed cup
闪点(°C)
-23 °C - closed cup
法规信息
危险化学品
此项目有
alpha.-Oxoketene dithioacetal chemistry. 2. Conjugate reductions with electrophilic reducing agents.
Gammill R
The Journal of Organic Chemistry, 46(17), 3555-3558 (1981)
Chemoselective Reduction of Esters to Aldehydes by Potassium Diisobutyl-t-butoxyaluminum Hydride (PDBBA).
Chae MJ, et al.
Bull. Korean Chem. Soc., 28(12), 2517-2517 (2007)
Hidetsura Cho et al.
The Journal of organic chemistry, 75(3), 627-636 (2009-12-31)
A systematic investigation of the reductive ring-expansion reaction of cyclic ketoximes fused to aromatic rings with diisobutylaluminum hydride (DIBALH) is described. This reaction regioselectively afforded a variety of five- to eight-membered bicyclic heterocycles or tricyclic heterocycles containing nitrogen neighboring an
D J Kopecky et al.
The Journal of organic chemistry, 65(1), 191-198 (2000-05-18)
An optimized protocol for the DIBALH reductive acetylation of acyclic esters and diesters is described. This reductive acetylation procedure allows a wide variety of esters to be converted into the corresponding alpha-acetoxy ethers in good to excellent yields. It was
J Marco-Contelles et al.
Carbohydrate research, 335(1), 63-70 (2001-09-13)
The reaction of DIBALH with bis(heteroannulated)-pyranosides containing the perhydrofuro[2,3-b]pyran moiety is described. The hydride attack at the anomeric carbon (C-9a) resulted in the exclusive tetrahydrofuran ring opening. The selectivity of this reaction has been evaluated as other benzylidene acetals built
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