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Merck
CN

191892

Sigma-Aldrich

羟丙基纤维素

average Mw ~370,000, powder, 20 mesh particle size (99% through)

别名:

HPC

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MDL编号:
UNSPSC代码:
12162002
NACRES:
NA.23
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描述

biological oxygen demand (BOD) 14,000 ppm

质量水平

表单

powder

自燃温度

752 °F

分子量

average Mw ~370,000

杂质

<5 wt. %

粒径

20 mesh (99% through)

pH值(酸碱度)

5.0-8.5

界面张力矿物油

12.5 dyn/cm, 0.1 wt. % in H2O (vs. mineral oil)

粘度

150-400 cP, 2 wt. % in H2O(25 °C, Brookfield, spindle #2) (60 rpm)(lit.)

溶解性

H2O: insoluble (above 45 °C)
polar organic solvents: soluble

密度

0.5 g/mL at 25 °C (lit.)

SMILES字符串

N(C)(C)c1cc(c(cc1)C(N)CC)C

InChI

1S/C12H20N2/c1-5-12(13)11-7-6-10(14(3)4)8-9(11)2/h6-8,12H,5,13H2,1-4H3

InChI key

RRHXDYJWVYFMKV-UHFFFAOYSA-N

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一般描述

羟丙基纤维素(HPC)是一种非离子衍生物纤维素。它是一种热敏、可生物降解的聚合物,具有较低的临界溶液温度。

应用

羟丙基纤维素可 用于制备用于药物递送系统的复合纳米球。 甲基丙烯酸羟丙酯/羟基纤维素接枝共聚物 可用作控释片的基质。 它也可以用作电解质添加剂,制备用于染料敏化太阳能电池的凝胶聚合物电解质。

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Satomi Onoue et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 46(5), 492-499 (2012-04-14)
The present study was undertaken to develop a solid self-emulsifying drug delivery system of coenzyme Q(10) (CoQ(10)/s-SEDDS) with high photostability and oral bioavailability. The CoQ(10)/s-SEDDS was prepared by spray-drying an emulsion preconcentrate containing CoQ(10), medium-chain triglyceride, sucrose ester of fatty
Ranjit M Dhenge et al.
International journal of pharmaceutics, 438(1-2), 20-32 (2012-09-11)
The present work focuses on the study of the progression of granules in different compartments along the length of screws in a twin screw granulator (TSG). The effects of varying powder feed rate; liquid to solid ratio and viscosity of
Hyemin Choi et al.
Journal of pharmaceutical sciences, 101(8), 2941-2951 (2012-05-26)
Living organisms secrete minerals composed of peptides and proteins, resulting in "mesocrystals" of three-dimensional-assembled composite structures. Recently, this biomimetic polymer-directed crystallization technique has been widely applied to inorganic materials, although it has seldom been used with drugs. In this study
Weibin Deng et al.
Drug development and industrial pharmacy, 39(2), 290-298 (2012-04-25)
The objective of this study was to improve the dissolution rate and to enhance the stability of a poorly water-soluble and low glass-trasition temperature (T(g)) model drug, fenofibrate, in low molecular weight grades of hydroxypropylcellulose matrices produced by hot-melt extrusion
Alexandre Monteiro et al.
Drug development and industrial pharmacy, 39(2), 266-283 (2012-04-17)
Nanoparticles of BCS Class II drugs are produced in wet stirred media mills operating in batch or recirculation mode with the goal of resolving the poor water-solubility issue. Scant information is available regarding the continuous production of drug nanoparticles via

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