一般描述
4-Biphenylacetic acid is a potential non-steroidal antiinflammatory agent and forms solid inclusion complex with β-cyclodextrin. 4-Biphenylacetic acid on interaction with quinolone antibacterial agents induces functional blockade of the γ-aminobutyric acid receptors.
应用
4-Biphenylacetic acid was used in the synthesis of gastrosparing non-steroidal antiinflammatory drug.
警示用语：
Danger
危险分类
Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
G Puglisi et al.
The Journal of pharmacy and pharmacology, 43(6), 430-432 (1991-06-01)
4-Biphenylacetic acid, a potent non-steroidal anti-inflammatory agent forms a solid inclusion complex with beta-cyclodextrin in a 1:1 molar ratio, which exhibits better solubility and dissolution characteristics than the uncomplexed drug. Following oral administration of the complex to rats, quicker and
N Yi Mok et al.
Journal of medicinal chemistry, 56(5), 1843-1852 (2013-02-05)
β-Secretase (BACE1), the enzyme responsible for the first and rate-limiting step in the production of amyloid-β peptides, is an attractive target for the treatment of Alzheimer's disease. In this study, we report the application of the de novo fragment-based molecular
Liqing Zang et al.
Zebrafish, 8(4), 203-210 (2011-12-21)
A novel protocol using gluten as a carrier material was developed to administer chemicals to adult zebrafish, per os (p.o.). To evaluate the capacity of gluten to retain chemicals, we prepared gluten granules containing eight types of chemicals with different
Ananda Sarkar et al.
Journal of molecular modeling, 15(10), 1221-1228 (2009-03-07)
Cyclooxygenase (COX) is a well-known enzyme, which converts arachidonic acid to prostaglandins H(2) (PGH(2)), which are the effective mediators of inflammation. 4', 5 di-substituted 3-biphenyl acetic acids (BPA) and several alpha-methyl derivatives (MBPA) of it are widely used as powerful
R F Halliwell et al.
Neuropharmacology, 43(4), 778-787 (2002-10-09)
A hybrid molecule composed of the antimicrobial, norfloxacin, linked to the non-steroidal anti-inflammatory drug (NSAID), biphenylacetic acid, which we have termed norbiphen, is a lethal convulsant in vivo and an antagonist of rodent GABA(A) receptors in vitro. In the present
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