300764
1,2,3,4-四氢-9H-吡啶并[3,4-b]吲哚
98%
别名:
Tetrahydronorharmane, Tryptoline
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关于此项目
经验公式（希尔记法）:
C11H12N2
化学文摘社编号:
分子量:
172.23
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
产品名称
1,2,3,4-四氢-9H-吡啶并[3,4-b]吲哚, 98%
InChI
1S/C11H12N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-4,12-13H,5-7H2
SMILES string
C1Cc2c(CN1)[nH]c3ccccc23
InChI key
CFTOTSJVQRFXOF-UHFFFAOYSA-N
assay
98%
form
liquid
mp
206-208 °C (lit.)
Quality Level
Gene Information
rat ... Htr2a(29595), Htr2c(25187)
Application
用于生物碱的合成以及用于研究神经退行性疾病。
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General description
Ozonolysis of the enamine bond of 1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole derivatives was studied.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Chem. Abstr., 121, 54854s-54854s (1994)
I M McDonald et al.
Journal of medicinal chemistry, 43(19), 3518-3529 (2000-09-23)
A novel series of nonpeptide CCK(2) receptor antagonists has been prepared, in which 2,7-dioxo-2,3,4,5,6,7-hexahydro-1H-benzo[h][1, 4]diazonine (5) was used as a chemical template. This uncommon ring system was obtained in a highly substituted form and in high yield by ozonolysis of
J. Chin. Chem. Soc., 41, 231-231 (1994)
Fang-Yuan Chang et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(7), 2478-2483 (2013-01-11)
Natural product discovery by random screening of broth extracts derived from cultured bacteria often suffers from high rates of redundant isolation, making it ever more challenging to identify novel biologically interesting natural products. Here we show that homology-based screening of
Jutamas Jiaranaikulwanitch et al.
Bioorganic & medicinal chemistry letters, 20(22), 6572-6576 (2010-10-15)
Tryptoline, a core structure of ochrolifuanine E, which is a hit compound from virtual screening of the Thai herbal database against BACE1 was used as a scaffold for the design of BACE1 inhibitors. The tryptoline was linked with different side
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