346616
1,2-萘醌
97%
别名:
β-萘醌
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关于此项目
经验公式（希尔记法）:
C10H6O2
化学文摘社编号:
分子量:
158.15
EC Number:
208-360-2
UNSPSC Code:
12352100
PubChem Substance ID:
Beilstein/REAXYS Number:
606546
MDL number:
Assay:
97%
Form:
powder
InChI key
KETQAJRQOHHATG-UHFFFAOYSA-N
InChI
1S/C10H6O2/c11-9-6-5-7-3-1-2-4-8(7)10(9)12/h1-6H
SMILES string
O=C1C=Cc2ccccc2C1=O
assay
97%
form
powder
mp
139-142 °C (dec.) (lit.)
functional group
ketone
Gene Information
human ... PTPRC(5788)
General description
1,2-萘醌是萘的主要代谢产物之一，它负责发挥其相关的细胞毒性和遗传毒性。 1,2-萘醌是一种大气污染物。它通过激活表皮生长因子受体，引起豚鼠气管平滑肌的收缩。 据报道，1,2-萘醌是柴油废气颗粒（DEP）和大气颗粒物中的环境醌。
Application
在利用扫描电化学显微镜（SECM）对正常人乳房（MCF-10A）细胞的氧化还原活性进行电化学作图时，1,2-萘醌被用作介质。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
B Liu et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(18), 9855-9860 (2000-08-30)
Electrochemical methods have been widely used to monitor physiologically important molecules in biological systems. This report describes the first application of the scanning electrochemical microscope (SECM) to probe the redox activity of individual living cells. The possibilities of measuring the
Shota Kikuno et al.
Toxicology and applied pharmacology, 210(1-2), 47-54 (2005-07-26)
1,2-Naphthoquinone (1,2-NQ) has recently been identified as an environmental quinone in diesel exhaust particles (DEP) and atmospheric PM2.5. We have found that this quinone is capable of causing a concentration-dependent contraction of tracheal smooth muscle in guinea pigs with EC50
Suramya Waidyanatha et al.
Chemico-biological interactions, 141(3), 189-210 (2002-10-19)
Naphthalene-1,2-oxide (NPO), 1,2-naphthoquinone (1,2-NPQ) and 1,4-naphthoquinone (1,4-NPQ) are the major metabolites of naphthalene that are thought to be responsible for the cytotoxicity and genotoxicity of this chemical. We measured cysteinyl adducts of these metabolites in hemoglobin (Hb) and albumin (Alb)
Graham M Pumphrey et al.
Microbiology (Reading, England), 153(Pt 11), 3730-3738 (2007-11-03)
This study was designed to characterize naphthalene metabolism in Polaromonas naphthalenivorans CJ2. Comparisons were completed using two archetypal naphthalene-degrading bacteria: Pseudomonas putida NCIB 9816-4 and Ralstonia sp. strain U2, representative of the catechol and gentisate pathways, respectively. Strain CJ2 carries
Hsueh-Cheng Chiang et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 23(6), 1969-1977 (2009-03-04)
To determine how endogenously secreted beta-amyloid 42 (Abeta42) aggregates regulate synaptic functions, we examined effects of Abeta42 at the neuromuscular junction of Drosophila larvae. Voltage-clamp recordings of synaptic transmission and optical analysis of vesicle recycling at presynaptic terminals show that
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