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346616

1,2-萘醌

Name: 1,2-萘醌
Brand: ALDRICH

97%

别名:

β-萘醌

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关于此项目

经验公式（希尔记法）:

C₁₀H₆O₂

化学文摘社编号:

524-42-5

分子量:

158.15

EC Number:

208-360-2

UNSPSC Code:

12352100

PubChem Substance ID:

24861421

Beilstein/REAXYS Number:

606546

MDL number:

MFCD00001698

Assay:

97%

Form:

powder

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属性

assay

97%

form

powder

mp

139-142 °C (dec.) (lit.)

functional group

ketone

SMILES string

O=C1C=Cc2ccccc2C1=O

InChI

1S/C10H6O2/c11-9-6-5-7-3-1-2-4-8(7)10(9)12/h1-6H

InChI key

KETQAJRQOHHATG-UHFFFAOYSA-N

Gene Information

human ... PTPRC(5788)

说明

General description

1,2-萘醌是萘的主要代谢产物之一，它负责发挥其相关的细胞毒性和遗传毒性。 1,2-萘醌是一种大气污染物。它通过激活表皮生长因子受体，引起豚鼠气管平滑肌的收缩。据报道，1,2-萘醌是柴油废气颗粒（DEP）和大气颗粒物中的环境醌。

Application

在利用扫描电化学显微镜（SECM）对正常人乳房（MCF-10A）细胞的氧化还原活性进行电化学作图时，1,2-萘醌被用作介质。

pictograms

GHS07

signalword

Warning

hcodes

H302,H315,H319,H335

pcodes

P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Scanning electrochemical microscopy of living cells: different redox activities of nonmetastatic and metastatic human breast cells.

B Liu et al.

Proceedings of the National Academy of Sciences of the United States of America, 97(18), 9855-9860 (2000-08-30)

Electrochemical methods have been widely used to monitor physiologically important molecules in biological systems. This report describes the first application of the scanning electrochemical microscope (SECM) to probe the redox activity of individual living cells. The possibilities of measuring the

1,2-Naphthoquinone activates vanilloid receptor 1 through increased protein tyrosine phosphorylation, leading to contraction of guinea pig trachea.

Shota Kikuno et al.

Toxicology and applied pharmacology, 210(1-2), 47-54 (2005-07-26)

1,2-Naphthoquinone (1,2-NQ) has recently been identified as an environmental quinone in diesel exhaust particles (DEP) and atmospheric PM2.5. We have found that this quinone is capable of causing a concentration-dependent contraction of tracheal smooth muscle in guinea pigs with EC50

Measurement of hemoglobin and albumin adducts of naphthalene-1,2-oxide, 1,2-naphthoquinone and 1,4-naphthoquinone after administration of naphthalene to F344 rats.

Suramya Waidyanatha et al.

Chemico-biological interactions, 141(3), 189-210 (2002-10-19)

Naphthalene-1,2-oxide (NPO), 1,2-naphthoquinone (1,2-NPQ) and 1,4-naphthoquinone (1,4-NPQ) are the major metabolites of naphthalene that are thought to be responsible for the cytotoxicity and genotoxicity of this chemical. We measured cysteinyl adducts of these metabolites in hemoglobin (Hb) and albumin (Alb)

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货号	GTIN
346616-5G	04061826761274
346616-1G	04061826761250