348902
(S)-5-羟甲基二氢呋喃-2-酮
95%
别名:
(S)-γ-羟甲基-γ-丁内酯, (S)-4,5-二氢-5-羟甲基-2(3H)-呋喃酮, (S)-5-羟甲基-2-氧代四氢呋喃
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关于此项目
经验公式（希尔记法）:
C5H8O3
化学文摘社编号:
分子量:
116.12
Beilstein:
1680284
MDL编号:
UNSPSC代码:
12352005
PubChem化学物质编号:
NACRES:
NA.22
方案
95%
表单
liquid
旋光性
[α]20/D +56°, c = 3 in chloroform
光学纯度
ee: 98% (GLC)
折射率
n20/D 1.471 (lit.)
沸点
110-115 °C/0.2 mmHg (lit.)
密度
1.237 g/mL at 25 °C (lit.)
储存温度
2-8°C
SMILES字符串
OC[C@@H]1CCC(=O)O1
InChI
1S/C5H8O3/c6-3-4-1-2-5(7)8-4/h4,6H,1-3H2/t4-/m0/s1
InChI key
NSISJFFVIMQBRN-BYPYZUCNSA-N
一般描述
Dihydro-5-(hydroxymethyl)-2(3H)-furanone is a chiral building block widely used in the synthesis of many natural products and few biologically significant compounds like anti-HIV dideoxynucleosides. It is also used in the synthesis of optically active ligands.
应用
(S)-(+)-Dihydro-5-(hydroxymethyl)-2(3H)-furanone can be used as a chiral synthon to synthesize:
- Potent nucleoside, acetylcholine, and (+)-muricatacin analogs.
- Mevinic acids, which are LDL cholesterol-lowering agents.
- Adenine based anti-HIV agent named β-F-ddA.
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
235.4 °F - closed cup
闪点(°C)
113 °C - closed cup
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
A concise synthesis of anti-viral agent F-ddA, starting from (S)-dihydro-5-(hydroxymethyl)-2 (3H)-furanone
Choudhury A, et al.
Tetrahedron Letters, 44(2), 247-250 (2003)
Blackwell, C.M. et al.
The Journal of Organic Chemistry, 57, 5597-5597 (1992)
Enantio-and diastereoisomers of 2, 4-dimethoxy-5-(2, 3-dideoxy-5-O-tritylribofuranosyl) pyrimidine. 2′, 3′-Dideoxy pyrimidine C-nucleosides by palladium-mediated glycal-aglycon coupling
Zhang HC and Daves Jr GD
The Journal of Organic Chemistry, 58(9), 2557-2560 (1993)
Stereospecific synthesis of (+)-muricatacin: a biologically active acetogenin derivative
Figadere B, et al.
Tetrahedron Letters, 32(51), 7539-7542 (1991)
Total synthesis of dihydromevinolin and a series of related 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors
Blackwell CM, et al.
The Journal of Organic Chemistry, 57(21), 5596-5606 (1992)
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