373605
6,6′-二硫二烟酸
technical grade, 85%
别名:
双[3-羧基吡啶] 6,6′-二硫化物, 双[3-羧基吡啶] 6,6′-二硫醚
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关于此项目
经验公式（希尔记法）:
C12H8N2O4S2
化学文摘社编号:
分子量:
308.33
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
239-729-6
MDL number:
Assay:
85%
Form:
solid
grade
technical grade
Quality Level
assay
85%
form
solid
mp
263-265 °C (lit.)
functional group
carboxylic acid, disulfide
SMILES string
OC(=O)c1ccc(SSc2ccc(cn2)C(O)=O)nc1
InChI
1S/C12H8N2O4S2/c15-11(16)7-1-3-9(13-5-7)19-20-10-4-2-8(6-14-10)12(17)18/h1-6H,(H,15,16)(H,17,18)
InChI key
GSASOFRDSIKDSN-UHFFFAOYSA-N
General description
6,6′-Dithiodinicotinic acid is reported as sulphydryl reagent. 6,6′-Dithiodinicotinic acid is reported to react with thiols, to afford a disulfide and 6-mercaptonicotinic acid. Interaction of 6,6′-dithiodinicotinic acid with the homogenates of Ehrlich ascites cells has been reported.
Application
6,6′-Dithiodinicotinic acid may be employed as:
- specific thiol blocker to investigate the radioprotective effect of mercaptoethylamine on the thiol level of the outer cell membrane of the Ehrlich ascites tumor cells
- modifier to investigate the polar microenvironment around the reactive Cys283 of rabbit muscle creatine kinase
- dipyridyl-dithio substrate to evaluate the protein disulfide-thiol interchange activity of the auxin stimulated NADH: protein disulfide reductase (NADH oxidase) of soybean plasma membranes
- water-soluble reagent in a study for introducing, in buffered saline, a reactive sulfhydryl group on water-soluble molecules bearing an alkyl-amino group
- chromogen for sulfhydryl groups in the Ellman method for cholinesterase determinations
- spectrophotometric determination of thiols and of total glutathione in human blood
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Metastases limited.
D R Grassetti
Nature, 308(5959), 500-500 (1984-04-05)
M M Konstantinova et al.
Radiobiologiia, 28(3), 364-368 (1988-05-01)
In experiments with Ehrlich ascites tumor cells, using a specific thiol blocker, 6,6'-dithiodinicotinic acid, that does not penetrate the cell and therefore only binds SH-groups of peripheral areas of an external cell membrane, it was demonstrated that (1) the external
L Meunier et al.
Bioconjugate chemistry, 10(2), 206-212 (1999-03-17)
A simple method for introducing, in buffered saline, a reactive sulfhydryl group on water-soluble molecules bearing an alkyl-amino group is described. This method is based on the use of two water-soluble reagents: 2-iminothiolane and 6,6'-dithiodinicotinic acid. The first one is
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 373605-5G | 04061831834581 |