373605
6,6′-二硫二烟酸
technical grade, 85%
别名:
双[3-羧基吡啶] 6,6′-二硫化物, 双[3-羧基吡啶] 6,6′-二硫醚
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关于此项目
经验公式（希尔记法）:
C12H8N2O4S2
化学文摘社编号:
分子量:
308.33
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
239-729-6
MDL number:
产品名称
6,6′-二硫二烟酸, technical grade, 85%
InChI key
GSASOFRDSIKDSN-UHFFFAOYSA-N
InChI
1S/C12H8N2O4S2/c15-11(16)7-1-3-9(13-5-7)19-20-10-4-2-8(6-14-10)12(17)18/h1-6H,(H,15,16)(H,17,18)
SMILES string
OC(=O)c1ccc(SSc2ccc(cn2)C(O)=O)nc1
grade
technical grade
assay
85%
form
solid
mp
263-265 °C (lit.)
functional group
carboxylic acid
disulfide
Quality Level
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Application
6,6′-Dithiodinicotinic acid may be employed as:
- specific thiol blocker to investigate the radioprotective effect of mercaptoethylamine on the thiol level of the outer cell membrane of the Ehrlich ascites tumor cells
- modifier to investigate the polar microenvironment around the reactive Cys283 of rabbit muscle creatine kinase
- dipyridyl-dithio substrate to evaluate the protein disulfide-thiol interchange activity of the auxin stimulated NADH: protein disulfide reductase (NADH oxidase) of soybean plasma membranes
- water-soluble reagent in a study for introducing, in buffered saline, a reactive sulfhydryl group on water-soluble molecules bearing an alkyl-amino group
- chromogen for sulfhydryl groups in the Ellman method for cholinesterase determinations
- spectrophotometric determination of thiols and of total glutathione in human blood
General description
6,6′-Dithiodinicotinic acid is reported as sulphydryl reagent. 6,6′-Dithiodinicotinic acid is reported to react with thiols, to afford a disulfide and 6-mercaptonicotinic acid. Interaction of 6,6′-dithiodinicotinic acid with the homogenates of Ehrlich ascites cells has been reported.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Timo Wille et al.
Toxicology mechanisms and methods, 21(7), 533-537 (2011-04-08)
For the diagnosis and therapy monitoring of intoxications with organophosphorus compounds, the determination of acetylcholinesterase (AChE) activity in whole blood is crucial. Usually, this testing is done with the colorimetric Ellman test using 412 nm wavelength and 5,5'-dithiobis-nitrobenzoic acid (DTNB) as
Labeling of thiols involved in the activity of complex V of the mitochondrial oxidative phosphorylation system.
C Godinot et al.
The Journal of biological chemistry, 256(13), 6776-6782 (1981-07-10)
J Nishiyama et al.
Analytical biochemistry, 138(1), 95-98 (1984-04-01)
A simple and rapid method for the determination of nanomole levels of biological thiols is described. The analysis is based on the combination of reverse-phase high-performance liquid chromatography with a postcolumn reaction with 6,6'-dithiodinicotinic acid. Thiols, including cysteine, cysteamine, thiolhistidine
S Willig et al.
Veterinary and human toxicology, 38(4), 249-253 (1996-08-01)
The Ellman method for cholinesterase determination is a spectrophotometric method which entails the use of 5,5'-dithiobis-(2-nitrobenzoic) acid (DTNB) as a chromogen and records the level of cholinesterase activity as the change in absorbance at 412 nm. Although this procedure commonly
The interaction of 6,6'-dithiodinicotinic acid with thiols and with ehrlich ascites tumor cells.
D R Grassetti et al.
Biochemical pharmacology, 18(3), 603-611 (1969-03-01)
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