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373605

6,6′-二硫二烟酸

Name: 6,6′-二硫二烟酸
Brand: ALDRICH

technical grade, 85%

别名:

双[3-羧基吡啶] 6,6′-二硫化物, 双[3-羧基吡啶] 6,6′-二硫醚

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关于此项目

经验公式（希尔记法）:

C₁₂H₈N₂O₄S₂

化学文摘社编号:

15658-35-2

分子量:

308.33

NACRES:

NA.22

PubChem Substance ID:

24863248

UNSPSC Code:

12352100

EC Number:

239-729-6

MDL number:

MFCD00006454

Assay:

85%

Form:

solid

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属性

grade

technical grade

Quality Level

200

assay

85%

form

solid

mp

263-265 °C (lit.)

functional group

carboxylic acid, disulfide

SMILES string

OC(=O)c1ccc(SSc2ccc(cn2)C(O)=O)nc1

InChI

1S/C12H8N2O4S2/c15-11(16)7-1-3-9(13-5-7)19-20-10-4-2-8(6-14-10)12(17)18/h1-6H,(H,15,16)(H,17,18)

InChI key

GSASOFRDSIKDSN-UHFFFAOYSA-N

说明

General description

6,6′-Dithiodinicotinic acid is reported as sulphydryl reagent. 6,6′-Dithiodinicotinic acid is reported to react with thiols, to afford a disulfide and 6-mercaptonicotinic acid. Interaction of 6,6′-dithiodinicotinic acid with the homogenates of Ehrlich ascites cells has been reported.

Application

6,6′-Dithiodinicotinic acid may be employed as:

specific thiol blocker to investigate the radioprotective effect of mercaptoethylamine on the thiol level of the outer cell membrane of the Ehrlich ascites tumor cells
modifier to investigate the polar microenvironment around the reactive Cys283 of rabbit muscle creatine kinase
dipyridyl-dithio substrate to evaluate the protein disulfide-thiol interchange activity of the auxin stimulated NADH: protein disulfide reductase (NADH oxidase) of soybean plasma membranes
water-soluble reagent in a study for introducing, in buffered saline, a reactive sulfhydryl group on water-soluble molecules bearing an alkyl-amino group
chromogen for sulfhydryl groups in the Ellman method for cholinesterase determinations
spectrophotometric determination of thiols and of total glutathione in human blood

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000507776

0000237940

0000210532

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Validation of the use of 6,6'-dithiodinicotinic acid as a chromogen in the Ellman method for cholinesterase determinations.

S Willig et al.

Veterinary and human toxicology, 38(4), 249-253 (1996-08-01)

The Ellman method for cholinesterase determination is a spectrophotometric method which entails the use of 5,5'-dithiobis-(2-nitrobenzoic) acid (DTNB) as a chromogen and records the level of cholinesterase activity as the change in absorbance at 412 nm. Although this procedure commonly

Labeling of thiols involved in the activity of complex V of the mitochondrial oxidative phosphorylation system.

C Godinot et al.

The Journal of biological chemistry, 256(13), 6776-6782 (1981-07-10)

The interaction of 6,6'-dithiodinicotinic acid with thiols and with ehrlich ascites tumor cells.

D R Grassetti et al.

Biochemical pharmacology, 18(3), 603-611 (1969-03-01)

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货号	GTIN
373605-5G	04061831834581