37580
3,4-二羟基苯甲酸
≥97.0% (T)
别名:
原儿茶酸
质量水平
方案
≥97.0% (T)
mp
197-200 °C (dec.) (lit.)
官能团
carboxylic acid
SMILES字符串
OC(=O)c1ccc(O)c(O)c1
InChI
1S/C7H6O4/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3,8-9H,(H,10,11)
InChI key
YQUVCSBJEUQKSH-UHFFFAOYSA-N
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一般描述
据报道，3,4-二羟基苯甲酸是一种食品多酚。在小鼠模型中，3,4-二羟基苯甲酸（原儿茶酸，PCA）对毒性H9N2病毒株的抗病毒活性已有报道。PCA对3种非小细胞肺癌（NSCLC）细胞系（A549、H3255和Calu-6细胞系）的细胞毒性作用已有报道。据报道，PCA可在体内预防癌变或抗肿瘤生长。PCA诱导的人胃腺癌（AGS）细胞凋亡的相关信号通路已有报道。水/针铁矿料浆中的H2O2在不同操作条件（催化剂负载、温度、酸碱度、底物和过氧化氢起始浓度）下，对3，4-二羟苯甲酸的氧化作用已有研究。
应用
3,4-二羟基苯甲酸适用于在体内研究4-香豆酸和3,4-二羟基苯甲酸对大鼠结肠黏膜基础氧化性DNA损伤的影响。它可用于壳聚糖树脂的衍生化。
生化/生理作用
几个致癌作用的动物模型中的化学防癌剂。在后启动阶段阻断细胞增殖。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Francesco Guglielmi et al.
The British journal of nutrition, 89(5), 581-587 (2003-05-02)
The effect of 4-coumaric and 3,4-dihydroxybenzoic (protocatechuic) acid on the basal oxidative DNA damage of rat colonic mucosa in vivo was studied, relative to vitamin E. F344 rats were treated with 4-coumaric or protocatechuic acid mixed in the diet (25
Akhmad Sabarudin et al.
Analytica chimica acta, 581(2), 214-220 (2007-03-28)
A chitosan resin derivatized with 3,4-dihydroxybenzoic acid moiety (CCTS-DHBA resin) was newly synthesized for the collection/concentration of trace uranium by using cross-linked chitosan (CCTS) as base material, and the adsorption behavior of uranium as well as 60 elements on the
Hui-Hsuan Lin et al.
International journal of cancer, 120(11), 2306-2316 (2007-02-17)
3,4-Dihydroxybenzoic acid (protocatechuic acid, PCA) is discussed to represent antioxidative food components in a human diet rich in fruits and vegetables, and has been shown to prevent carcinogenesis or antitumor growth in vivo. However, the molecular mechanisms involved in chemopreventive
Shih-ming Tsao et al.
Nutrition and cancer, 66(8), 1331-1341 (2014-10-31)
Cytotoxic effects of protocatechuic acid (PCA) upon 3 nonsmall cell lung cancer (NSCLC) cell lines, A549, H3255, and Calu-6 cell lines, were examined. PCA at 1, 2, 4, and 8 μM was used to treat these cells. Results showed that
Roberto Andreozzi et al.
Water research, 36(11), 2761-2768 (2002-07-31)
The oxidation by H2O2 of 3,4-dihydroxybenzoic acid (3,4-DHB) in aqueous/goethite slurry at varying operating conditions (catalyst load, temperature, pH, substrate and hydrogen peroxide starting concentration) is investigated. At adopted catalyst loads the observed kinetic developments are consistent with a non-radicalic
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