421235
1-(2-嘧啶基)哌嗪
98%
别名:
2-(1-哌嗪基)嘧啶
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关于此项目
经验公式（希尔记法）:
C8H12N4
分子量:
164.21
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
244-135-5
MDL number:
Assay:
98%
InChI key
MRBFGEHILMYPTF-UHFFFAOYSA-N
InChI
1S/C8H12N4/c1-2-10-8(11-3-1)12-6-4-9-5-7-12/h1-3,9H,4-7H2
SMILES string
C1CN(CCN1)c2ncccn2
assay
98%
refractive index
n20/D 1.587 (lit.)
bp
277 °C (lit.)
density
1.158 g/mL at 25 °C (lit.)
General description
1-（2-嘧啶基）哌嗪是一种基于哌嗪的衍生物。它是丁螺环酮的代谢产物。
Application
1-（2-嘧啶基）哌嗪可用于以下研究：
- 作为多肽羧基的衍生试剂。
- 磷酸肽分光光度分析过程中的羧基衍生化。
- 用于合成 3-{{（4-（嘧啶-2-基）哌嗪-1-基）甲基 }-1 H -吡咯并 [2,3- b ] 吡啶的起始试剂。
- 3-苯基-6-（4-（嘧啶-2-基）哌嗪-1-基）哒嗪-4-醇的合成。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
>230.0 °F
flash_point_c
> 110 °C
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Xiaoqiang Qiao et al.
Rapid communications in mass spectrometry : RCM, 25(5), 639-646 (2011-02-04)
Piperazine-based derivatives, including 1-(2-pyridyl)piperazine (2-PP), 1-(2-pyrimidyl)piperazine (2-PMP), 1-(4-pyridyl)piperazine (4-PP), and 1-(1-methyl-4-piperidinyl)piperazine (M-PP), were used for the derivatization of carboxyl groups on peptides with 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) and 1-hydroxy-7-azabenzotriazole (HOAt) as coupling reagents, and trifluoroacetic acid (TFA) as activator. Taking synthetic
M Hascoët et al.
Pharmacology, biochemistry, and behavior, 67(1), 45-53 (2000-12-13)
Although numerous animal procedures have been employed in the study of antidepressants (ADs) in anxiety, the results following acute administration remain highly variable. The present study investigated the effect of the SSRI paroxetine (4, 8, and 16 mg/kg, IP) in
K T Kivistö et al.
Therapeutic drug monitoring, 21(3), 317-321 (1999-06-12)
Two separate gas chromatographic methods for the determination of buspirone and its active metabolite, 1-(2-pyrimidinyl)-piperazine (1-PP) in human plasma are described. Both procedures involve solid-phase extraction (the packing material of the cartridges used was C8 for buspirone and a mixed-mode
J Odontiadis et al.
Journal of pharmaceutical and biomedical analysis, 14(3), 347-351 (1996-01-01)
Buspirone is a member of the azapirone group of anxiolytic drugs and has one major metabolite, 1-(2-pyrimidinyl)piperazine (1-PP). The analyte, its metabolite and the internal standard were extracted from plasma utilizing solid-phase extraction columns. Chromatography was performed using isocratic reversed-phase
A H Vaidya et al.
Methods and findings in experimental and clinical pharmacology, 27(4), 245-255 (2005-08-06)
Most studies concerning the effects of oral buspirone in the rat elevated plus-maze (EPM) test, spontaneous motor activity (SMA) test, and Vogel conflict (VC) test have used Sprague-Dawley or Wistar rats. Although it has been documented that the behavior of
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