产品名称
1-(2-嘧啶基)哌嗪, 98%
InChI key
MRBFGEHILMYPTF-UHFFFAOYSA-N
InChI
1S/C8H12N4/c1-2-10-8(11-3-1)12-6-4-9-5-7-12/h1-3,9H,4-7H2
SMILES string
C1CN(CCN1)c2ncccn2
assay
98%
refractive index
n20/D 1.587 (lit.)
bp
277 °C (lit.)
density
1.158 g/mL at 25 °C (lit.)
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Application
1-（2-嘧啶基）哌嗪可用于以下研究：
- 作为多肽羧基的衍生试剂。
- 磷酸肽分光光度分析过程中的羧基衍生化。
- 用于合成 3-{{（4-（嘧啶-2-基）哌嗪-1-基）甲基 }-1 H -吡咯并 [2,3- b ] 吡啶的起始试剂。
- 3-苯基-6-（4-（嘧啶-2-基）哌嗪-1-基）哒嗪-4-醇的合成。
General description
1-（2-嘧啶基）哌嗪是一种基于哌嗪的衍生物。它是丁螺环酮的代谢产物。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
>230.0 °F
flash_point_c
> 110 °C
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
J Odontiadis et al.
Journal of pharmaceutical and biomedical analysis, 14(3), 347-351 (1996-01-01)
Buspirone is a member of the azapirone group of anxiolytic drugs and has one major metabolite, 1-(2-pyrimidinyl)piperazine (1-PP). The analyte, its metabolite and the internal standard were extracted from plasma utilizing solid-phase extraction columns. Chromatography was performed using isocratic reversed-phase
I Mahmood et al.
Clinical pharmacokinetics, 36(4), 277-287 (1999-05-13)
Buspirone is an anxiolytic drug given at a dosage of 15 mg/day. The mechanism of action of the drug is not well characterised, but it may exert its effect by acting on the dopaminergic system in the central nervous system
K T Kivistö et al.
Therapeutic drug monitoring, 21(3), 317-321 (1999-06-12)
Two separate gas chromatographic methods for the determination of buspirone and its active metabolite, 1-(2-pyrimidinyl)-piperazine (1-PP) in human plasma are described. Both procedures involve solid-phase extraction (the packing material of the cartridges used was C8 for buspirone and a mixed-mode
A H Vaidya et al.
Methods and findings in experimental and clinical pharmacology, 27(4), 245-255 (2005-08-06)
Most studies concerning the effects of oral buspirone in the rat elevated plus-maze (EPM) test, spontaneous motor activity (SMA) test, and Vogel conflict (VC) test have used Sprague-Dawley or Wistar rats. Although it has been documented that the behavior of
K T Kivistö et al.
Pharmacology & toxicology, 84(2), 94-97 (1999-03-06)
The effects of inhibition and induction of the metabolism of buspirone on the plasma concentrations of 1-(2-pyrimidinyl)-piperazine (a piperazine metabolite), the principal active metabolite of buspirone, were investigated. Two separate randomized, placebo-controlled cross-over studies with two phases were carried out
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