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421235

1-(2-嘧啶基)哌嗪

Name: 1-(2-嘧啶基)哌嗪
Brand: ALDRICH

98%

别名:

2-(1-哌嗪基)嘧啶

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关于此项目

经验公式（希尔记法）:

C₈H₁₂N₄

分子量:

164.21

NACRES:

NA.22

PubChem Substance ID:

24866373

UNSPSC Code:

12352100

EC Number:

244-135-5

MDL number:

MFCD00040742

Assay:

98%

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属性

assay

98%

refractive index

n20/D 1.587 (lit.)

bp

277 °C (lit.)

density

1.158 g/mL at 25 °C (lit.)

SMILES string

C1CN(CCN1)c2ncccn2

InChI

1S/C8H12N4/c1-2-10-8(11-3-1)12-6-4-9-5-7-12/h1-3,9H,4-7H2

InChI key

MRBFGEHILMYPTF-UHFFFAOYSA-N

说明

General description

1-（2-嘧啶基）哌嗪是一种基于哌嗪的衍生物。它是丁螺环酮的代谢产物。

Application

1-（2-嘧啶基）哌嗪可用于以下研究：

作为多肽羧基的衍生试剂。
磷酸肽分光光度分析过程中的羧基衍生化。
用于合成 3-{{（4-（嘧啶-2-基）哌嗪-1-基）甲基 }-1 H -吡咯并 [2,3- b ] 吡啶的起始试剂。
3-苯基-6-（4-（嘧啶-2-基）哌嗪-1-基）哒嗪-4-醇的合成。

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

10 - Combustible liquids

wgk

WGK 3

flash_point_f

>230.0 °F

flash_point_c

> 110 °C

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Buspirone modulates basal and fluoxetine-stimulated dialysate levels of dopamine, noradrenaline and serotonin in the frontal cortex of freely moving rats: activation of serotonin1A receptors and blockade of alpha2-adrenergic receptors underlie its actions.

A Gobert et al.

Neuroscience, 93(4), 1251-1262 (1999-09-29)

The serotonin1A receptor partial agonist, buspirone, also displays antagonist properties at D2 receptors and is metabolized to the alpha2-adrenergic receptor antagonist, 1-(2-pyrimidinyl-piperazine). Herein, we examined mechanisms underlying the influence of buspirone alone, and in association with the serotonin reuptake inhibitor

Comparative behavioural profiles of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine (1-PP) in the murine elevated plus-maze.

B J Cao et al.

Neuropharmacology, 36(8), 1089-1097 (1997-08-01)

It has been suggested that in vivo formation of the metabolite 1-(2-pyrimidinyl)-piperazine (1-PP) may be a major drawback in the use of buspirone as an anti-anxiety agent. To test this hypothesis, the effects of buspirone, alone or with proadifen (an

Piperazines for peptide carboxyl group derivatization: effect of derivatization reagents and properties of peptides on signal enhancement in matrix-assisted laser desorption/ionization mass spectrometry.

Xiaoqiang Qiao et al.

Rapid communications in mass spectrometry : RCM, 25(5), 639-646 (2011-02-04)

Piperazine-based derivatives, including 1-(2-pyridyl)piperazine (2-PP), 1-(2-pyrimidyl)piperazine (2-PMP), 1-(4-pyridyl)piperazine (4-PP), and 1-(1-methyl-4-piperidinyl)piperazine (M-PP), were used for the derivatization of carboxyl groups on peptides with 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) and 1-hydroxy-7-azabenzotriazole (HOAt) as coupling reagents, and trifluoroacetic acid (TFA) as activator. Taking synthetic

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421235-5G	04061832093734
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