495964
3-（二乙氧基磷酰基）-1,2,3-苯并三嗪-4 (3 H )-酮
98%
别名:
DEPBT
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关于此项目
经验公式（希尔记法）:
C11H14N3O5P
化学文摘社编号:
分子量:
299.22
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
方案
98%
mp
72-75 °C (lit.)
SMILES字符串
CCOP(=O)(OCC)ON1N=Nc2ccccc2C1=O
InChI
1S/C11H14N3O5P/c1-3-17-20(16,18-4-2)19-14-11(15)9-7-5-6-8-10(9)12-13-14/h5-8H,3-4H2,1-2H3
InChI key
AJDPNPAGZMZOMN-UHFFFAOYSA-N
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一般描述
3-(Diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one (DEPBT) is a coupling reagent that facilitates amide bond formation and also resists racemization. It has been shown to be more effective than phosphonium and uronium coupling reagents.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
监管及禁止进口产品
此项目有
H Li et al.
Organic letters, 1(1), 91-93 (2000-05-24)
[formula: see text] The new crystalline phosphate reagent 3-(diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one (DEPBT) mediates amide bond formation with a remarkable resistance to racemization. Comparative racemization studies were carried out and DEPBT proved to be superior to typical phosphonium and uronium coupling reagents. DEPBT
Yun-Hua Ye et al.
Biopolymers, 80(2-3), 172-178 (2005-01-01)
3-(Diethoxyphosphoryloxy)-1, 2, 3-benzotriazin-4(3H)-one (DEPBT) is an effective coupling reagent for synthesis of linear and cyclic peptides by both solution and solid-phase peptide synthesis. DEPBT mediates amide bond formation with remarkable resistance to racemization. When DEPBT is used as a coupling
New reagents, reactions, and peptidomimetics for drug design.
Goodman M, et al.
Pept. Sci., 60(3), 229-245 (2001)
Daniel Herkommer et al.
ChemMedChem, 10(3), 470-489 (2015-02-03)
The natural products rhizopodin and bistramide belong to an elite class of highly potent actin binding agents. They show powerful antiproliferative activities against a range of tumor cell lines, with IC50 values in the low-nanomolar range. At the molecular level
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