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Merck
CN

516414

1-(苯磺酰)-3-吲哚甲醛

97%

别名:

1-(Benzenesulfonyl)indole-3-carboxaldehyde, 1-(Phenylsulfonyl)-3-formylindole, NSC 628191

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关于此项目

经验公式(希尔记法):
C15H11NO3S
化学文摘社编号:
分子量:
285.32
UNSPSC Code:
12352100
PubChem Substance ID:
MDL number:
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InChI

1S/C15H11NO3S/c17-11-12-10-16(15-9-5-4-8-14(12)15)20(18,19)13-6-2-1-3-7-13/h1-11H

SMILES string

[H]C(=O)c1cn(c2ccccc12)S(=O)(=O)c3ccccc3

InChI key

ZLARITBCJILRBL-UHFFFAOYSA-N

assay

97%

form

solid

mp

157-161 °C (lit.)

Application

Reactant for:
  • Peterson olefination

Reactant for preparation of:
  • Antifungal agents
  • Potential topoisomerase II inhibitors
  • Anti-inflammatory, analgesic and anticonvulsant agents
  • Bacteriorhodopsin analogs
  • Antitumor agents
  • Antitubercular agents
  • Inhibitors of human dUTPase and UNG2
  • Uracil DNA glycosylase inhibitor
  • Anti-HIV and anti-tumor β-carbolines

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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Ming-Zhi Zhang et al.
European journal of medicinal chemistry, 53, 283-291 (2012-05-09)
A simple and efficient synthetic protocol for 5-(3-indolyl)-oxazoles has been developed and further used to synthesize a series of novel analogues of natural product pimprinine. All new compounds were identified by (1)H NMR, high resolution mass spectrometry, and the structures
Bo Cheng et al.
Organic letters, 12(16), 3622-3625 (2010-08-14)
A concise synthesis of (+/-)-pseudotabersonine from commercially available 1-(phenylsulfonyl)-3-indolecarboxaldehyde has been accomplished. This synthesis features the convergent assembly of a key intermediate via a stepwise variant of a Mannich-type multicomponent coupling process, a double ring-closing metathesis, and a one-pot deprotection/cyclization

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