766305
Bis(2-cyanoethyl)-N,N-diisopropylphosphoramidite
95%
别名:
Bis(2-cyanoethoxy)(diisopropylamino)phosphine, Bis(2-cyanoethoxy)-N,N-diisopropylaminophosphine
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关于此项目
经验公式（希尔记法）:
C12H22N3O2P
化学文摘社编号:
分子量:
271.30
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
95%
Form:
liquid
InChI
1S/C12H22N3O2P/c1-11(2)15(12(3)4)18(16-9-5-7-13)17-10-6-8-14/h11-12H,5-6,9-10H2,1-4H3
SMILES string
CC(C)N(C(C)C)P(OCCC#N)OCCC#N
InChI key
LDHWBEHZLFDXCU-UHFFFAOYSA-N
assay
95%
form
liquid
refractive index
n20/D 1.465
density
1.039 g/mL at 25 °C
storage temp.
−20°C
Quality Level
General description
Useful phosphorylating reagent used in oligonucleotide synthesis for adding a terminal phosphate group to the 3′ or 5′ hydroxyl.
Application
Bis(2-cyanoethyl)-N,N-diisopropylphosphoramidite may be used as a phosphitylating agent during the multi-step synthesis of (-)-1L-chiro-inositol 2,3,5-trisphosphate starting from L-quebrachitol.
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
165.0 °F
flash_point_c
73.9 °C
Synthesis from quebrachitol of 1L-chiro-inositol 2, 3, 5-trisphosphate, an inhibitor of the enzymes of 1D-myo-inositol 1, 4, 5-trisphosphate metabolism.
Liu C, et al.
Carbohydrate Research, 234, 107-115 (1992)
Seigo Nagata et al.
Nucleic acids research, 38(21), 7845-7857 (2010-07-28)
Though medicines that target mRNA are under active investigation, there has been little or no effort to develop mRNA itself as a medicine. Here, we report the synthesis of a 130-nt mRNA sequence encoding a 33-amino-acid peptide that includes the
Inhibition of glutamate carboxypeptidase by phosphoryl and thiophosphoryl derivatives of glutamic and 2-hydroxyglutaric acid.
Lu H, et al.
Phosph. Sulfur Relat. Elem., 178(1), 17-32 (2003)
Florian Abele et al.
Biomolecules, 10(4) (2020-04-02)
The complexity of the transcriptome is governed by the intricate interplay of transcription, RNA processing, translocation, and decay. In eukaryotes, the removal of the 5'-RNA cap is essential for the initiation of RNA degradation. In addition to the canonical 5'-N7-methyl
Sequence-specific recognition and cleavage of duplex DNA via triple-helix formation by oligonucleotides covalently linked to a phenanthroline-copper chelate.
Francois JC, et al.
Proceedings of the National Academy of Sciences of the USA, 86(24), 9702-9706 (1989)
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