777129
N,N-Diethylmethacrylamide
contains <500 ppm MEHQ as inhibitor, 97%
别名:
DEMAAM, DEMAM
方案
97%
表单
liquid
包含
<500 ppm MEHQ as inhibitor
折射率
n20/D 1.455
密度
0.901 g/mL at 25 °C
储存温度
2-8°C
SMILES字符串
CCN(CC)C(=O)C(C)=C
InChI
1S/C8H15NO/c1-5-9(6-2)8(10)7(3)4/h3,5-6H2,1-2,4H3
InChI key
JMCVCHBBHPFWBF-UHFFFAOYSA-N
一般描述
Post polymerization, N, N-Diethyl methacrylamide gels show temperature sensitivity because of their lower critical solution temperature (LCST). This acrylamide is commonly polymerized to form temperature sensitive hydrogels. The presence of a hydrophobic group (methyl and ethyl group in this case) is characteristic in temperature sensitive polymers. Water solubility in such polymers decreases with increase in temperature.
应用
Since the lower critical solution temperature (LCST) is around body temperature, it is widely used in the development of drug delivery systems based on the sol gel phase conversion at body temperature.
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
183.0 °F
闪点(°C)
83.88 °C
Drug release behavior of a pH/temperature sensitive calcium alginate/poly(N-acryloylglycine) bead with
core-shelled structure
core-shelled structure
Deng KL, et al.
Express Polymer Letters, 4(12), 773-780 (2010)
Y Qiu et al.
Advanced drug delivery reviews, 53(3), 321-339 (2001-12-18)
Environmentally sensitive hydrogels have enormous potential in various applications. Some environmental variables, such as low pH and elevated temperatures, are found in the body. For this reason, either pH-sensitive and/or temperature-sensitive hydrogels can be used for site-specific controlled drug delivery.
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