777129
N,N-Diethylmethacrylamide
contains <500 ppm MEHQ as inhibitor, 97%
别名:
DEMAAM, DEMAM
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关于此项目
经验公式（希尔记法）:
C8H15NO
化学文摘社编号:
分子量:
141.21
NACRES:
NA.23
PubChem Substance ID:
UNSPSC Code:
12162002
MDL number:
InChI
1S/C8H15NO/c1-5-9(6-2)8(10)7(3)4/h3,5-6H2,1-2,4H3
SMILES string
CCN(CC)C(=O)C(C)=C
InChI key
JMCVCHBBHPFWBF-UHFFFAOYSA-N
assay
97%
form
liquid
contains
<500 ppm MEHQ as inhibitor
refractive index
n20/D 1.455
density
0.901 g/mL at 25 °C
storage temp.
2-8°C
General description
Post polymerization, N, N-Diethyl methacrylamide gels show temperature sensitivity because of their lower critical solution temperature (LCST). This acrylamide is commonly polymerized to form temperature sensitive hydrogels. The presence of a hydrophobic group (methyl and ethyl group in this case) is characteristic in temperature sensitive polymers. Water solubility in such polymers decreases with increase in temperature.
Application
Since the lower critical solution temperature (LCST) is around body temperature, it is widely used in the development of drug delivery systems based on the sol gel phase conversion at body temperature.
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
183.0 °F
flash_point_c
83.88 °C
Drug release behavior of a pH/temperature sensitive calcium alginate/poly(N-acryloylglycine) bead with
core-shelled structure
core-shelled structure
Deng KL, et al.
Express Polymer Letters, 4(12), 773-780 (2010)
Y Qiu et al.
Advanced drug delivery reviews, 53(3), 321-339 (2001-12-18)
Environmentally sensitive hydrogels have enormous potential in various applications. Some environmental variables, such as low pH and elevated temperatures, are found in the body. For this reason, either pH-sensitive and/or temperature-sensitive hydrogels can be used for site-specific controlled drug delivery.
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