791806
4-氨基-2,3,5,6-四氟三氟甲苯
97%
别名:
2,3,5,6-四氟-4-三氟甲基苯胺
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关于此项目
线性分子式:
CF3C6F4NH2
化学文摘社编号:
分子量:
233.09
Beilstein:
2657893
MDL编号:
UNSPSC代码:
12352101
PubChem化学物质编号:
NACRES:
NA.22
质量水平
方案
97%
表单
liquid
反应适用性
reaction type: C-C Bond Formation
reagent type: catalyst
reaction type: C-H Activation
折射率
n20/D 1.431 (lit.)
n20/D 1.432
沸点
186 °C (lit.)
密度
1.662 g/mL at 25 °C
1.687 g/mL at 25 °C (lit.)
官能团
fluoro
SMILES字符串
Nc1c(F)c(F)c(c(F)c1F)C(F)(F)F
InChI
1S/C7H2F7N/c8-2-1(7(12,13)14)3(9)5(11)6(15)4(2)10/h15H2
InChI key
FJOACTZFMHZHSC-UHFFFAOYSA-N
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其他说明
Acidic amides are superior directing groups for promoting C-H activation reactions with both Pd(0)/PR3 and Pd(II) catalysts.
Used in the Preparation of
Used in the Preparation of
- Lactams via palladium-catalyzed olefination of arylamides with benzylacrylate, followed by 1,4-conjugate addition
- N-(fluorinated aryl)benzamides as substrates for regioselective C-H amination reactions with O-benzoylhydroxylamines
- Substituted succinimides via palladium-catalyzed carbonylation of N-aryl amides
- N-aryl cyclopropanecarboxamide substrates and various amino acid ligands for palladium-catalyzed C-H activation of cyclopropanes
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Wasa, M;
Journal of the American Chemical Society, 132(11), 3680-3681 null
Eun Jeong Yoo et al.
Journal of the American Chemical Society, 133(20), 7652-7655 (2011-04-28)
C-H amination of N-aryl benzamides with O-benzoyl hydroxylamines has been achieved with either Pd(II) or Pd(0) catalysts. Furthermore, we demonstrate that secondary amines can be directly used with benzoyl peroxide in a one-pot procedure that proceeds via the in situ
Palladium(0)-Catalyzed Alkynylation of C(sp3)-H Bonds
He, J.:
Journal of the American Chemical Society null
Eun Jeong Yoo et al.
Journal of the American Chemical Society, 132(49), 17378-17380 (2010-11-19)
Pd(II)-catalyzed β-C(sp(3))-H carbonylation of N-arylamides under CO (1 atm) has been achieved. Following amide-directed C(sp(3))-H cleavage and insertion of CO into the resulting [Pd(II)-C(sp(3))] bond, intramolecular C-N reductive elimination gave the corresponding succinimides, which could be readily converted to 1,4-dicarbonyl
Masayuki Wasa et al.
Journal of the American Chemical Society, 133(49), 19598-19601 (2011-11-09)
Systematic ligand development has led to the identification of novel mono-N-protected amino acid ligands for Pd(II)-catalyzed enantioselective C-H activation of cyclopropanes. A diverse range of organoboron reagents can be used as coupling partners, and the reaction proceeds under mild conditions.
相关内容
Yu program focuses on efficient C–H bond activation for drug synthesis, using simple starting materials.
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