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Merck
CN

857556

4-乙氧基亚甲基-2-苯基-2-恶唑啉-5-酮

technical grade

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经验公式(希尔记法):
C12H11NO3
化学文摘社编号:
分子量:
217.22
UNSPSC Code:
12352100
PubChem Substance ID:
EC Number:
239-713-9
MDL number:
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InChI key

SJHPCNCNNSSLPL-NTMALXAHSA-N

InChI

1S/C12H11NO3/c1-2-15-8-10-12(14)16-11(13-10)9-6-4-3-5-7-9/h3-8H,2H2,1H3/b10-8-

SMILES string

CCO\C=C1/N=C(OC1=O)c2ccccc2

grade

technical grade

mp

94-96 °C (dec.) (lit.)

storage temp.

2-8°C

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pictograms

Exclamation mark

signalword

Warning

hcodes

pcodes

Hazard Classifications

Skin Sens. 1

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

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Mijung Yeom et al.
Journal of dermatological science, 67(2), 101-110 (2012-06-26)
Irritant contact dermatitis (ICD) is an inflammatory skin disease triggered by exposure to a chemical that is toxic or irritating to the skin. A major characteristic of chronic ICD is an inflammatory dry-skin condition with associated itching. Although glucosylceramide (GlcCer)
Boyi Liu et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(9), 3549-3563 (2013-06-01)
Allergic contact dermatitis is a common skin disease associated with inflammation and persistent pruritus. Transient receptor potential (TRP) ion channels in skin-innervating sensory neurons mediate acute inflammatory and pruritic responses following exogenous stimulation and may contribute to allergic responses. Genetic
Amanda Waddell et al.
Inflammatory bowel diseases, 21(12), 2737-2746 (2015-08-28)
IL-33, a member of the IL-1 cytokine family that signals through ST2, is upregulated in ulcerative colitis (UC); however, the role of IL-33 in colitis remains unclear. IL-33 augments type 2 immune responses, which have been implicated in UC pathogenesis.
Kenjyo Miyauchi et al.
Nature chemical biology, 9(2), 105-111 (2012-12-18)
N(6)-threonylcarbamoyladenosine (t(6)A) is a universally conserved, essential modified nucleoside found in transfer RNAs (tRNAs) responsible for ANN codons in all three domains of life. t(6)A has a crucial role in maintaining decoding accuracy during protein synthesis. The presence of t(6)A
Zenghui Lu et al.
The Journal of organic chemistry, 77(21), 9871-9877 (2012-10-11)
A novel palladium-catalyzed approach for the assembly of 3,4,5-trisubstituted oxazolones has been achieved by the coupling of N-alkynyl tert-butyloxycarbamates with aryl halides and related electrophiles, which involves an oxidative addition followed by oxypalladation/reductive elimination. The reaction provides a convenient access

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