900258
Isopropoxy(phenyl)silane
别名:
RubenSilane
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经验公式（希尔记法）:
C9H14OSi
化学文摘社编号:
分子量:
166.29
MDL number:
UNSPSC Code:
12352005
NACRES:
NA.22
InChI key
XYMAHMLQCLMTDN-UHFFFAOYSA-N
InChI
1S/C9H14OSi/c1-8(2)10-11-9-6-4-3-5-7-9/h3-8H,11H2,1-2H3
SMILES string
[SiH2](OC(C)C)c1ccccc1
form
liquid
reaction suitability
reagent type: reductant
reaction type: Reductions
refractive index
n/D 1.4799
density
0.926 g/mL
storage temp.
2-8°C
Quality Level
Application
Isopropoxy(phenyl)silane can be used as a hydride source for alkene hydrofunctionalization reactions in the presence of metal catalysts, particularly under aprotic, nonalcoholic conditions. This reagent is considered as one of the most efficient stoichiometric reductants than phenylsilane because of its ability to exclude alcohol solvent from a series of catalytic reactions. When utilized, it allows the researcher to significantly decrease catalyst loadings, lower reaction temperatures, and employ more diverse solvents in iron- and manganese-catalyzed Mukaiyama hydrofunctionalizations.
It can be used as a reagent in:
It can be used as a reagent in:
- The hydrogenation of olefins
- Branch-selective olefin cross-coupling reactions
- Markovnikov alkene hydration/amination reactions
General description
Isopropoxy(phenyl)silane is used as a stoichiometric reductant that allows for a significant decrease in catalyst loading, lower reaction temperatures, a wide range of functional group tolerance, and more diverse solvents in metal-catalyzed Mukaiyama hydrofunctionalizations.
存储类别
10 - Combustible liquids
wgk
WGK 3
Isopropoxy (phenyl) silane
Demoret RM and Shenvi RA
eEROS (Encyclopedia of Reagents for Organic Synthesis) (2001)
Carla Obradors et al.
Journal of the American Chemical Society, 138(14), 4962-4971 (2016-03-18)
We report the discovery of an outstanding reductant for metal-catalyzed radical hydrofunctionalization reactions. Observations of unexpected silane solvolysis distributions in the HAT-initiated hydrogenation of alkenes reveal that phenylsilane is not the kinetically preferred reductant in many of these transformations. Instead
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