902314
[CpRu(Fmoc-tyrosin)]CF3CO2
别名:
Fmoc-protected ruthenium tyrosine amino acid derivative, Peptide radiolabel precursor, [18F]Fluorophenylalanine peptide residue precursor
SMILES string
O[C]1[CH][CH][C](CC(NC(OCC2C(C=CC=C3)=C3C4=C2C=CC=C4)=O)C(O)=O)[CH][CH]1.F[C-](F)F.O=C=O.[Ru+].c5cccc5
form
powder
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
mp
>300 °C
application(s)
peptide synthesis
functional group
Fmoc
storage temp.
2-8°C
Application
The Ritter lab has developed a new method for direct labeling of polypeptides with the [18F]fluoride radiolabel. This Fmoc-protected ruthenium tyrosine is first incorporated into peptides, which is amenable to standard solid-phase peptide synthesis (SPPS) and is tolerant of all 20 canonical amino acids. Subsequent replacement of a single hydrogen with fluorine-18, with only minimal perturbation of the peptide structure, results in a site-specific, radiolabeled peptide tracer for use with positron emission tomography (PET) imaging in the study of various biological applications.
Legal Information
Patent Application EP18204755.5
This product is manufactured pursuant to a license with Studiengesellschaft Kohle mbH
This product is manufactured pursuant to a license with Studiengesellschaft Kohle mbH
Disclaimer
Research quantities limited to 10 g.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Jens Rickmeier et al.
Angewandte Chemie (International ed. in English), 57(43), 14207-14211 (2018-09-07)
Radiolabeled receptor-binding peptides are an important class of positron emission tomography tracers owing to achievable high binding affinities and their rapid blood clearance. Herein, a method to introduce a 4-[18 F]fluoro-phenylalanine residue into peptide sequences is reported, by chemoselective radio-deoxyfluorination
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