914487
2-(Diphenylphosphanyl)benzamide
≥95%
别名:
2-(Diphenylphosphino)-benzamide, DPBM, Phosphine for Staundinger reduction
质量水平
方案
≥95%
表单
powder
储存温度
−20°C
SMILES字符串
P(c3c(cccc3)C(=O)N)(c2ccccc2)c1ccccc1
InChI
1S/C19H16NOP/c20-19(21)17-13-7-8-14-18(17)22(15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H,(H2,20,21)
InChI key
IHGZKYLRNBICEF-UHFFFAOYSA-N
一般描述
It is recommended to make fresh stock stolutions prior to each use.
应用
2-(Diphenylphosphanyl)benzamide (DPBM) is a phosphine useful in the Staudinger reduction in chemical biology and medicinal chemistry. Recently, DPBM was demonstrated to faciliate the reactivation of CRISPR/Cas9 functions by removing azidomethylnicotinyl (AMN) groups used to masked gRNA and inhibit CRISPR systems. AMN groups were originally added with the use of RNA probe NAI-N3 (cat# 913812).
储存分类代码
11 - Combustible Solids
WGK
WGK 3
Shao-Ru Wang et al.
Nature communications, 11(1), 91-91 (2020-01-05)
Prokaryotes use repetitive genomic elements termed CRISPR (clustered regularly interspaced short palindromic repeats) to destroy invading genetic molecules. Although CRISPR systems have been widely used in DNA and RNA technology, certain adverse effects do occur. For example, constitutively active CRISPR
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