一般描述
Oligo(poly(ethylene glycol) fumarate) (OPF) is a derivative of poly(ethylene glycol) (PEG). The unsaturated fumarate groups render it crosslinkable and biodegradable, with tunable mechanical properties. The multiple double bonds along the linear macromolecular chain allow for crosslinking in aqueous solutions in the presence of thermal, chemical or photochemical radical initiators.
应用
- Biomedical applications
- Drug delivery
- Tissue engineering
- 3D bioprinting
特点和优势
- Biodegradable and cytocompatible
- Crosslinkable
- Tunable mechanical properties
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
In vitro release of transforming growth factor-?1 from gelatin microparticles encapsulated in biodegradable, injectable oligo(poly(ethylene glycol) fumarate) hydrogels
Hollanda, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 91, 299-313 (2003)
Synthesis and Characterization of Oligo(poly(ethylene glycol) fumarate) Macromer.
Seongbong J, et al.
Macromolecules, 34, 2839-2844 (2001)
Mahrokh Dadsetan et al.
Biomacromolecules, 8(5), 1702-1709 (2007-04-11)
Photo-cross-linkable oligo[poly(ethylene glycol) fumarate] (OPF) hydrogels have been developed for use in tissue engineering applications. We demonstrated that compressive modulus of these hydrogels increased with increasing polymer concentration, and hydrogels with different mechanical properties were formed by altering the ratio
Heungsoo Shin et al.
Biomacromolecules, 4(3), 552-560 (2003-05-14)
Currently, oligo[poly(ethylene glycol) fumarate] (OPF) hydrogels are being investigated as an injectable and biodegradable system for tissue engineering applications. In this study, cytotoxicity of each component of the OPF hydrogel formulation and the resulting cross-linked network was examined. Specifically, OPF
Theresa A Holland et al.
Journal of controlled release : official journal of the Controlled Release Society, 101(1-3), 111-125 (2004-12-14)
This work describes the development of a non-invasive means of simultaneously delivering insulin-like growth factor-1 (IGF-1) and transforming growth factor-beta1 (TGF-beta1) to injured cartilage tissue in a controlled manner. This novel delivery technology employs the water-soluble polymer, oligo(poly(ethylene glycol) fumarate)
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