生物来源
(Streptococcus zooepidemicus)
质量水平
表单
powder or chunks (or fibers)
分子量
20-40 kDa (starting material)
颜色
white to faint yellow-brown
应用
3D bioprinting
advanced drug delivery
tissue engineering
(hydrogels)
储存温度
2-8°C
一般描述
Hyaluronic Acid methacrylate (HAMA) is an advanced biomaterial created by modifying natural hyaluronic acid with methacrylate groups, enabling photopolymerization capabilities. Hyaluronic acid (HA) is a linear polysaccharide composed of alternating D-glucuronic acid and N-acetyl-D-glucosamine. It occurs naturally in connective tissues, skin, cartilage, synovial fluid, and extracellular matrices throughout the body. The addition of methacrylate groups enables HAMA to be photo-crosslinkable, facilitating the formation of stable, crosslinked hydrogels. This biomaterial combines the inherent biocompatibility and bioactivity of hyaluronic acid with improved mechanical properties, making it well-suited for a wide range of applications in tissue engineering, 3D bioprinting, drug discovery, and medical devices.
应用
Tissue Engineering: Serves as a scaffold for cell attachment and proliferation, promoting the regeneration of various tissues, including cartilage, skin, and connective tissues, leveraging its ability to mimic the natural extracellular environment.
- 3D Bioprinting: Enables the precise fabrication of complex tissue structures, allowing for accurate cell placement and interaction.
- Drug Delivery: Facilitates the development of drug delivery systems and in vitro models for testing drug efficacy and safety.
- Medical Devices: Used in the production of hydrogels and coatings that enhance biocompatibility and functionality of medical implants and devices.
特点和优势
- Photocrosslinkable Chemistry: The methacrylate modification makes HAMA photo-crosslinkable, allowing for the creation of stable, crosslinked hydrogels with tunable mechanical properties.
- Enhanced Biocompatibility: Combines natural biocompatibility of hyaluronic acid with enhanced mechanical properties, supporting optimal cell-material interactions.
- Superior Water Retention: Excellent water retention capabilities create a hydrated environment that mimics natural tissues and supports cellular functions.
- Optimal Cell Environment: Provides an ideal environment for cell growth and differentiation, promoting tissue formation and regeneration.
- High Batch-to-Batch Consistency: R&D developed and tested for high batch-to-batch consistency with highly consistent starting materials, ensuring reproducible results for critical research and clinical applications.
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