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Merck
CN

A6057

Sigma-Aldrich

4-叠氮苯甲酰甲基溴

powder

别名:

4-叠氮-α-溴苯乙酮, 4′-叠氮-2-溴苯乙酮

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关于此项目

经验公式(希尔记法):
C8H6BrN3O
化学文摘社编号:
分子量:
240.06
Beilstein:
1961705
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
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表单

powder

反应适用性

reaction type: click chemistry
reagent type: cross-linking reagent

颜色

yellow

溶解性

methanol: 50 mg/mL

储存温度

2-8°C

SMILES字符串

BrCC(=O)c1ccc(cc1)N=[N+]=[N-]

InChI

1S/C8H6BrN3O/c9-5-8(13)6-1-3-7(4-2-6)11-12-10/h1-4H,5H2

InChI key

LZJPDRANSVSGOR-UHFFFAOYSA-N

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应用

光敏双异官能化交联剂。通常,初始反应在 7.0-8.0 的 pH 范围内偶联巯基。然后在紫外光 (250nm) 的照射下通过反应性氮烯发生二次键合。后一步的键合快速并且具有非特异性。

免责声明

还原剂(如硫醇)可将叠氮化物还原为胺类,所以应当避免还原剂出现在反应中。初始操作和偶联反应应当在弱光照条件下进行。

警示用语:

Danger

危险分类

Eye Dam. 1 - Flam. Sol. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1

储存分类代码

4.1B - Flammable solid hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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D Hu et al.
The Journal of biological chemistry, 275(4), 2705-2712 (2000-01-25)
The PI-SceI protein is an intein-encoded homing endonuclease that initiates the mobility of its gene by making a double strand break at a single site in the yeast genome. The PI-SceI protein splicing and endonucleolytic active sites are separately located
S H Hixson et al.
Biochemistry, 14(19), 4251-4254 (1975-09-23)
The synthesis of the photochemically labile bifunctional reagent p-azidophenacyl bromide (1) is described. This compound may be covalently attached to a known site of an enzyme or other macromolecule by nucleophilic displacement at the alpha-bromo ketone moiety. Subsequent irradiation of
M M Konarska
Methods (San Diego, Calif.), 18(1), 22-28 (1999-04-20)
Derivatization of RNA with heterobifunctional photocrosslinking reagents becomes an increasingly popular method for the analysis of structural properties of ribonucleoprotein complexes. This article describes a simple chemical modification-derivatization strategy used to introduce selected chemical groups at specific internal positions within
Vera Pingoud et al.
Journal of molecular biology, 329(5), 913-929 (2003-06-12)
We present here the first detailed biochemical analysis of an archaeal restriction enzyme. PspGI shows sequence similarity to SsoII, EcoRII, NgoMIV and Cfr10I, which recognize related DNA sequences. We demonstrate here that PspGI, like SsoII and unlike EcoRII or NgoMIV
J W Rausch et al.
The Journal of biological chemistry, 275(21), 16015-16022 (2000-04-05)
Cys(38) and Cys(280) of p66/p51 human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) can be converted to Ser without affecting enzyme function. We have exploited this feature to construct and purify "monocysteine" RT derivatives for site-specific modification with the

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