ALD00606
Wang−Yu non-directed C−H functionalization ligand
95%
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关于此项目
经验公式（希尔记法）:
C7H3F6NO
化学文摘社编号:
分子量:
231.10
UNSPSC Code:
12352200
NACRES:
NA.22
MDL number:
Assay:
95%
Form:
powder or crystals
SMILES string
FC(F)(F)c1c(ncc(c1)C(F)(F)F)O
InChI key
IWSJDZMIJFAEBO-UHFFFAOYSA-N
assay
95%
form
powder or crystals
reaction suitability
reaction type: C-C Bond Formation, reagent type: catalyst
reaction type: C-H Activation
mp
145 °C
storage temp.
−20°C
Application
This 2-pyridone ligand developed in the laboratory of Jin-Quan Yu binds to palladium and accelerates non-directed C-H functionalization. Developed for C-H olefination and carboxylation with arene as the limiting reagent, the Wang-Yu ligand enables diversification of drugs, synthetic intermediates, and other bioactive small molecules.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Peng Wang et al.
Angewandte Chemie (International ed. in English), 56(18), 5125-5129 (2017-04-04)
Meta-C-H functionalization of benzylamines has been developed using a PdII /transient mediator strategy. Using 2-pyridone ligands and 2-carbomethoxynorbornene (NBE-CO2 Me) as the mediator, arylation, amination, and chlorination of benzylamines are realized. This protocol features a broad substrate scope and is
Direct perfluoroalkylation including trifluoromethylation of aromatics with perfluoro carboxylic acids mediated by xenon difluoride.
Tanabe Y, et al.
The Journal of Organic Chemistry, 53 (19), 4582?4585-4582?4585 (1988)
Peng Wang et al.
Nature, 551(7681), 489-493 (2017-11-24)
The directed activation of carbon-hydrogen bonds (C-H) is important in the development of synthetically useful reactions, owing to the proximity-induced reactivity and selectivity that is enabled by coordinating functional groups. Palladium-catalysed non-directed C-H activation could potentially enable further useful reactions
Jin Lin et al.
Nature communications, 8, 14353-14353 (2017-02-07)
Catalytic oxidative C-H bond functionalization reactions that proceed without requiring stoichiometric amounts of external oxidants or pre-functionalized oxidizing reagents could maximize the atom- and step-economy in chemical syntheses. However, such a transformation remains elusive. Here, we report that a photo-driven
相关内容
Yu program focuses on efficient C–H bond activation for drug synthesis, using simple starting materials.
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