form
liquid
reaction suitability
reaction type: C-C Bond Formation
Application
Phenylsulfanyltetrafluoroethanesulfonyl fluoride serves as a moderately reactive phenylsulfanyltetrafluoroethanesulfonylation reagent. A phenylsulfanyltetrafluoroethyl moiety incorporated in the substrate can be treated with tributyltin hydride and generate the corresponding fluoroalkyl radical which can add to neighbouring olefins, creating tetrafluorinated carbocycles. If the substrate lacks any olefins, it can be reduced to a tetrafluoroethyl group. Generally, fluoroalkylsulfonylation of the amine nitrogen greatly lowers the pKa value of the N-H and can be used to modulate the behaviour of the drug candidate or build additional molecular complexity around the highly acidic fluoroalkylsulfonamide nitrogen.
Automate your fluorination reactions with Synple Automated Synthesis Platform (SYNPLE-SC002)
Automate your fluorination reactions with Synple Automated Synthesis Platform (SYNPLE-SC002)
Legal Information
Product of CF Plus Chemicals.
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Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
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商品
Fluoroalkylation toolbox expands with various reagents for late-stage fluoroalkylation in organic synthesis and medicinal chemistry.
目前的氟烷基化工具包括Togni试剂、高价碘全氟烷基化试剂、氟烷基溴化物、硅烷类和羧酸盐类以及用于后期氟烷基化的磺酰氟类。
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