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Merck
CN

T35009

L-甲状腺氨酸 钠盐 五水合物

99%

别名:

3-[4-(4-羟基-3,5-二碘苯氧基)-3,5-二碘苯基]-L-丙氨酸 钠盐, T4, 左甲状腺素钠

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关于此项目

线性分子式:
HOC6H2I2OC6H2I2CH2CH(NH2)COONa · 5H2O
化学文摘社编号:
6106-07-6
分子量:
888.93
EC Number:
200-221-4
UNSPSC Code:
12352103
MDL number:
MFCD00149110
Beilstein/REAXYS Number:
5721845

主要文件

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assay

99%

optical activity

[α]20/D −6.6°, c = 3 in 1 M NaOH, C2H5OH, 1:2

mp

207-210 (dec.) (lit.)

SMILES string

O.O.O.O.O.[Na+].N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C([O-])=O

InChI

1S/C15H11I4NO4.Na.5H2O/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23;;;;;;/h1-2,4-5,12,21H,3,20H2,(H,22,23);;5*1H2/q;+1;;;;;/p-1/t12-;;;;;;/m0....../s1

InChI key

JMHCCAYJTTWMCX-QWPJCUCISA-M

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Biochem/physiol Actions

L-甲状腺素（T4） 和三碘-L-甲状腺原氨酸（T3）是由甲状腺滤泡细胞中的甲状腺球蛋白产生的含碘激素。这些激素对代谢率的刺激和对生长发育的调节似乎是由于它们对 DNA 转录和蛋白质合成的影响。

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H372

Hazard Classifications

STOT RE 1

target_organs

Thyroid,Cardio-vascular system,Kidney

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
03612DV
15705KY
14512JO
11005DY
06404TB

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Inanc Birol et al.
PloS one, 10(6), e0130720-e0130720 (2015-06-30)
In this work we studied the liver transcriptomes of two frog species, the American bullfrog (Rana (Lithobates) catesbeiana) and the African clawed frog (Xenopus laevis). We used high throughput RNA sequencing (RNA-seq) data to assemble and annotate these transcriptomes, and
S Austin Hammond et al.
General and comparative endocrinology, 219, 6-15 (2015-01-15)
Thyroid hormones (THs) are essential for normal growth, development, and metabolic control in vertebrates. Their absolute requirement during amphibian metamorphosis provides a powerful means to detect and assess the impact of environmental contaminants on TH signaling in the field and
Nik Veldhoen et al.
Comparative biochemistry and physiology. Part D, Genomics & proteomics, 16, 99-105 (2015-10-16)
Postembryonic frog development requires a thyroid hormone (TH)-dependent metamorphic transition from an aquatic larva to a terrestrial frog. Such change in environment involves lung maturation in preparation for breathing air. However, little is known regarding the underlying molecular events and

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