A7300
N-乙酰苯醌亚胺
别名:
N-(4-Oxo-1-cyclohexa-2,5-dienylidene)acetamide, N-乙酰基 -对- 苯并醌亚胺, NAPQI
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关于此项目
经验公式（希尔记法）:
C8H7NO2
化学文摘社编号:
分子量:
149.15
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
InChI
1S/C8H7NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5H,1H3
SMILES string
CC(=O)\N=C1\C=CC(=O)C=C1
InChI key
URNSECGXFRDEDC-UHFFFAOYSA-N
form
solid
storage temp.
−70°C
Quality Level
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Application
反应物涉及：
- 氧化还原反应
- 氢卤化
- pH 依赖性反应：在酸性介质中，它被水解，在碱性介质中发生羟基化，并在中性 pH 下发生二聚化
- 对乙酰氨基酚肝毒性的调解
- 研究确定对乙酰氨基酚治疗自身免疫性疾病的效用
Disclaimer
空气、湿度和光敏感
Other Notes
对乙酰氨基酚代谢物，可与血清蛋白发生反应。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Johannes S Hoos et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 859(2), 147-156 (2007-10-05)
A generic method for the detection of covalent adducts to the cysteine-34 residue of human serum albumin (HSA) has been developed, based on an on-line combination of immunoaffinity chromatography for selective sample pre-treatment, solution phase digestion, liquid chromatography and tandem
Gregg V Crichlow et al.
Biochemistry, 48(1), 132-139 (2008-12-19)
Macrophage migration inhibitory factor (MIF) is a secreted protein expressed in numerous cell types that counters the antiinflammatory effects of glucocorticoids and has been implicated in sepsis, cancer, and certain autoimmune diseases. Interestingly, the structure of MIF contains a catalytic
Jean-Matthieu Prot et al.
Toxicology and applied pharmacology, 259(3), 270-280 (2012-01-11)
We have analyzed transcriptomic, proteomic and metabolomic profiles of hepatoma cells cultivated inside a microfluidic biochip with or without acetaminophen (APAP). Without APAP, the results show an adaptive cellular response to the microfluidic environment, leading to the induction of anti-oxidative
Shingo Arakawa et al.
The Journal of toxicological sciences, 37(3), 595-605 (2012-06-13)
We investigated the role of glutathione S-transferases Mu 1 (GSTM1) in acetaminophen (APAP)-induced hepatotoxicity using Gstm1-null mice. A single oral administration of APAP resulted in a marked increase in plasma alanine aminotransferase accompanied by hepatocyte necrosis 24 hr after administration
Amaresh Kumar Sahoo et al.
Nanoscale, 3(10), 4226-4233 (2011-09-08)
Herein, we report the generation of a composite comprised of p-hydroxyacetanilide dimer and Ag nanoparticles (NPs) by reaction of AgNO(3) and p-hydroxyacetanilide. The formation of the composite was established by UV-vis, FTIR and NMR spectroscopy, transmission electron microscopy and X-ray
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