A75900
1-氨基哌啶
97%
别名:
五亚甲基肼, 哌啶-1-基胺
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关于此项目
经验公式（希尔记法）:
C5H12N2
化学文摘社编号:
分子量:
100.16
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
218-666-8
MDL number:
产品名称
1-氨基哌啶, 97%
InChI key
LWMPFIOTEAXAGV-UHFFFAOYSA-N
InChI
1S/C5H12N2/c6-7-4-2-1-3-5-7/h1-6H2
SMILES string
NN1CCCCC1
assay
97%
form
liquid
refractive index
n20/D 1.475 (lit.)
bp
146 °C/730 mmHg (lit.)
density
0.928 g/mL at 25 °C (lit.)
Application
1-氨基哌啶可作为反应物与甲酸乙酯反应制得N-1-哌啶基甲酰胺。也与氢化铝、氢化镓反应生成相应的酰肼。在制药工业中，氨基哌啶被用作合成各种生物活性分子的构件。
用于合成以下物质的反应物：
- CB1大麻素受体配体†
- 腙类†
- 四氢萘衍生物对LPS激活RAW 264.7巨噬细胞增殖和一氧化氮生成的影响
- 磷（V）肼
Other Notes
剩余哌啶
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
96.8 °F - closed cup
flash_point_c
36 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
危险化学品
此项目有
N-Isocyanodialkylamines generated in situ for the Joullie-Ugi reaction with indolenines
Golubev P and Krasavin M
Tetrahedron Letters, 59(39), 3532-3536 (2018)
G Lunn et al.
Environmental and molecular mutagenesis, 17(1), 59-62 (1991-01-01)
When 1,1-dimethylhydrazine and N-aminopiperidine were deliberately exposed to air substantial amounts of the corresponding carcinogenic nitrosamines were formed. Unoxidized samples of 1,1-dimethylhydrazine were not mutagenic while oxidized samples (which contained much higher levels of nitrosamines) were mutagenic. Both unoxidized and
Inhibition of metabolism--mediated cytotoxicity by 1,1-disubstituted hydrazines in mouse mastocytoma cells (line P815).
P Wiebkin et al.
Advances in experimental medicine and biology, 136 Pt B, 1067-1075 (1981-01-01)
Synthesis, structure- activity relationship, and evaluation of SR141716 analogues: Development of central cannabinoid receptor ligands with lower lipophilicity
Katoch-Rouse R, et al.
Journal of Medicinal Chemistry, 46(4), 642-645 (2003)
Thomas Lübbers et al.
Bioorganic & medicinal chemistry letters, 17(11), 2966-2970 (2007-04-10)
In a search for novel DPP-IV inhibitors, 2-aminobenzo[a]quinolizines were identified as submicromolar HTS hits. Due to the difficult synthetic access to this compound class, 1,3-disubstituted 4-aminopiperidines were used as model compounds for optimization. The developed synthetic methodology and the SAR
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