C003
(R)-(-)-3-奎宁环基二苯乙醇酸酯
别名:
(R)-(-)-QNB, (R)-(-)-奎宁环基-α-羟基二苯基乙酸酯
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关于此项目
经验公式（希尔记法）:
C21H23NO3
化学文摘社编号:
分子量:
337.41
MDL编号:
UNSPSC代码:
12352005
PubChem化学物质编号:
NACRES:
NA.22
表单
solid
质量水平
储存温度
2-8°C
SMILES字符串
OC(C(=O)O[C@H]1CN2CCC1CC2)(c3ccccc3)c4ccccc4
InChI
1S/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2/t19-/m0/s1
InChI key
HGMITUYOCPPQLE-IBGZPJMESA-N
基因信息
rat ... Chrm1(25229), Chrm2(81645), Chrm3(24260)
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应用
(R)-(-)-3-Quinuclidinyl benzilate can be used as a reactant for the synthesis of quaternary ammonium derivatives of (3R)-quinuclidinol esters as potential muscarinic M3 antagonists. It can also be employed in the preparation of potent muscarinic cholinergic antagonist (R)-[N-methyl-3H]quinuclidinyl benzilate methiodide by alkylation with methyl iodide.
- Pharmacological agent used as muscarinic M3 antagonist for the inhaled treatment of chronic obstructive pulmonary disease (COPD)
生化/生理作用
非选择性毒蕈碱型乙酰胆碱受体拮抗剂。更有效的 QNB 对映体。
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Measurement of total acid number (TAN) and TAN boiling point distribution in petroleum products by electrospray ionization mass spectrometry
Q Kuangnan et al.
Analytical Chemistry, 80(3), 849-855 (2008)
A convenient synthesis of the muscarinic cholinergic antagonist (R)-[N-methyl-3H] quinuclidinyl benzilate methiodide
Filer CN and Seguin RJ
Journal of Labelled Compounds & Radiopharmaceuticals, 62(9), 604-607 (2019)
Qiaoying Lv et al.
Cancer letters, 442, 137-147 (2018-11-14)
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