C003
(R)-(-)-3-奎宁环基二苯乙醇酸酯
别名:
(R)-(-)-QNB, (R)-(-)-奎宁环基-α-羟基二苯基乙酸酯
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选择尺寸
关于此项目
经验公式（希尔记法）:
C21H23NO3
化学文摘社编号:
分子量:
337.41
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352005
MDL number:
Form:
solid
InChI key
HGMITUYOCPPQLE-IBGZPJMESA-N
SMILES string
OC(C(=O)O[C@H]1CN2CCC1CC2)(c3ccccc3)c4ccccc4
InChI
1S/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2/t19-/m0/s1
form
solid
storage temp.
2-8°C
Quality Level
Gene Information
rat ... Chrm1(25229), Chrm2(81645), Chrm3(24260)
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Biochem/physiol Actions
非选择性毒蕈碱型乙酰胆碱受体拮抗剂。更有效的 QNB 对映体。
Application
(R)-(-)-3-Quinuclidinyl benzilate can be used as a reactant for the synthesis of quaternary ammonium derivatives of (3R)-quinuclidinol esters as potential muscarinic M3 antagonists. It can also be employed in the preparation of potent muscarinic cholinergic antagonist (R)-[N-methyl-3H]quinuclidinyl benzilate methiodide by alkylation with methyl iodide.
- Pharmacological agent used as muscarinic M3 antagonist for the inhaled treatment of chronic obstructive pulmonary disease (COPD)
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
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Q Kuangnan et al.
Analytical Chemistry, 80(3), 849-855 (2008)
A convenient synthesis of the muscarinic cholinergic antagonist (R)-[N-methyl-3H] quinuclidinyl benzilate methiodide
Filer CN and Seguin RJ
Journal of Labelled Compounds & Radiopharmaceuticals, 62(9), 604-607 (2019)
Qiaoying Lv et al.
Cancer letters, 442, 137-147 (2018-11-14)
Continuous estrogen signaling is thought to be the main mechanism causing endometrial cancer (EC). Studies have demonstrated that CD163+ macrophages could promote the development of estrogen-dependent EC, but the mechanisms involved remain unclear. We found that CD163+ macrophages were the
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