H0751
尿黑酸
crystalline
别名:
2,5-二羟基苯乙酸
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关于此项目
线性分子式:
(HO)2C6H3CH2CO2H
化学文摘社编号:
分子量:
168.15
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
207-192-7
Beilstein/REAXYS Number:
2692860
MDL number:
Form:
crystalline
产品名称
尿黑酸, crystalline
InChI key
IGMNYECMUMZDDF-UHFFFAOYSA-N
InChI
1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)
SMILES string
OC(=O)Cc1cc(O)ccc1O
form
crystalline
color
off-white to tan
mp
150-152 °C (lit.)
storage temp.
2-8°C
Quality Level
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General description
尿黑酸（HGA）是在苯丙氨酸和酪氨酸分解代谢过程中形成的中间产物。 尿黑酸尿症是一种代谢紊乱，其特征是血清和尿液含有高浓度的HGA，这是由于缺乏与HGA降解有关的尿黑酸氧化酶。
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
Laura Tinti et al.
Rheumatology (Oxford, England), 50(2), 271-277 (2010-10-19)
Alkaptonuria (AKU) is a genetic disorder caused by lack of the enzyme responsible for breaking down homogentisic acid (HGA), an intermediate in tyrosine metabolism. HGA is deposited as a polymer, termed ochronotic pigment, in collagenous tissues. Pigmentation is progressive over
Huaixin Zheng et al.
Infection and immunity, 81(11), 4182-4191 (2013-08-28)
Iron acquisition is critical to the growth and virulence of Legionella pneumophila. Previously, we found that L. pneumophila uses both a ferrisiderophore pathway and ferrous iron transport to obtain iron. We now report that two molecules secreted by L. pneumophila
Homogentisic acid autoxidation and oxygen radical generation: implications for the etiology of alkaptonuric arthritis.
Martin Jr, et al.
Free Radical Biology & Medicine, 3(4), 241-250 (1987)
Corinne Raspail et al.
The Journal of biological chemistry, 286(29), 26061-26070 (2011-05-27)
4-Hydroxyphenylpyruvate dioxygenase (HPPD) catalyzes the conversion of 4-hydroxyphenylpyruvate (HPP) into homogentisate. HPPD is the molecular target of very effective synthetic herbicides. HPPD inhibitors may also be useful in treating life-threatening tyrosinemia type I and are currently in trials for treatment
V S Venkataseshan et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 5(4), 464-471 (1992-07-01)
In alkaptonuric ochronosis, the absence of homogentisic acid oxidase results in the accumulation of homogentisic acid in the body. Associated renal failure is rare and usually occurs in the later stages of the disease. We report a 19-yr-old girl who
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