H0751
尿黑酸
crystalline
别名:
2,5-二羟基苯乙酸
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关于此项目
线性分子式:
(HO)2C6H3CH2CO2H
化学文摘社编号:
分子量:
168.15
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
207-192-7
Beilstein/REAXYS Number:
2692860
MDL number:
产品名称
尿黑酸, crystalline
InChI key
IGMNYECMUMZDDF-UHFFFAOYSA-N
InChI
1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)
SMILES string
OC(=O)Cc1cc(O)ccc1O
form
crystalline
color
off-white to tan
mp
150-152 °C (lit.)
storage temp.
2-8°C
Quality Level
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General description
尿黑酸（HGA）是在苯丙氨酸和酪氨酸分解代谢过程中形成的中间产物。 尿黑酸尿症是一种代谢紊乱，其特征是血清和尿液含有高浓度的HGA，这是由于缺乏与HGA降解有关的尿黑酸氧化酶。
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
Yaping Wang et al.
BMC microbiology, 17(1), 122-122 (2017-05-27)
Combining experimental and computational screening methods has been of keen interest in drug discovery. In the present study, we developed an efficient screening method that has been used to screen 2100 small-molecule compounds for alanine racemase Alr-2 inhibitors. We identified
Chanika Phornphutkul et al.
The New England journal of medicine, 347(26), 2111-2121 (2002-12-27)
Alkaptonuria, caused by mutations in the HGO gene and a deficiency of homogentisate 1,2-dioxygenase, results in an accumulation of homogentisic acid (HGA), ochronosis, and destruction of connective tissue. There is no effective therapy for this disorder, although nitisinone inhibits the
A M Taylor et al.
Arthritis and rheumatism, 63(12), 3887-3896 (2011-12-01)
Alkaptonuria is a genetic disorder of tyrosine metabolism, resulting in elevated circulating concentrations of homogentisic acid. Homogentisic acid is deposited as a polymer, termed ochronotic pigment, in collagenous tissues, especially cartilages of weight-bearing joints, leading to a severe osteoarthropathy. We
Pediatric Dermatology E-Book, 507-507 (2011)
C Bory et al.
Clinica chimica acta; international journal of clinical chemistry, 189(1), 7-11 (1990-07-01)
The clinical and biochemical features of five cases of alcaptonuria were reported. The concentration of homogentisic acid was determined in urine and also in plasma using a rapid, sensitive and specific HPLC method. In all five cases, the concentrations of
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