M9775
4-(N-马来酰亚胺)二苯甲酮
别名:
二苯甲酮-4-马来酰亚胺
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关于此项目
经验公式（希尔记法）:
C17H11NO3
化学文摘社编号:
分子量:
277.27
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
InChI
1S/C17H11NO3/c19-15-10-11-16(20)18(15)14-8-6-13(7-9-14)17(21)12-4-2-1-3-5-12/h1-11H
SMILES string
O=C1C=CC(=O)N1c2ccc(cc2)C(=O)c3ccccc3
InChI key
OZIZEXQRIOURIJ-UHFFFAOYSA-N
reaction suitability
reagent type: cross-linking reagent
solubility
chloroform: 50 mg/mL, DMF: soluble
storage temp.
2-8°C
Application
含巯基特异性基团和光敏基团的双异官能化交联剂。通常，初始反应在 pH 为 6.8 (6.5-7.0) 时通过硫醚偶联至含游离巯基的分子。紫外光 (250nm) 照射的过程中通过双自由基激发态发生二次键合。二苯甲酮对 C-H 插入表现出更大的特异性并且在水中比类似试剂更稳定。一般说来，它们附接更有效，因为可对其反复照射；然而可能需要更强的照射。与类似试剂相比，二苯甲酮对还原反应不敏感。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Robert Ahrends et al.
Nucleic acids research, 34(10), 3169-3180 (2006-06-15)
To investigate protein-protein interaction sites in the DNA mismatch repair system we developed a crosslinking/mass spectrometry technique employing a commercially available trifunctional crosslinker with a thiol-specific methanethiosulfonate group, a photoactivatable benzophenone moiety and a biotin affinity tag. The XACM approach
Jessica DeLeon-Rangel et al.
FEBS letters, 587(7), 892-897 (2013-02-19)
The interaction of the membrane traversing stator subunits a and b of the rotary ATP synthase was probed by substitution of a single Cys into each subunit with subsequent Cu(2+) catalyzed cross-linking. Extensive interaction between the transmembrane (TM) region of
Anders Myrhammar et al.
Scientific reports, 10(1), 20777-20777 (2020-11-29)
Radionuclide molecular imaging of cancer-specific targets is a promising method to identify patients for targeted antibody therapy. Radiolabeled full-length antibodies however suffer from slow clearance, resulting in high background radiation. To overcome this problem, a pretargeting system based on complementary
Y K Doi et al.
Biochemistry, 30(23), 5769-5777 (1991-06-11)
The interaction of pig plasma gelsolin (G) and actin (A) was examined by using photoreactive 4-maleimidobenzophenone-actin (BPM-actin) in which BPM was previously conjugated to Cys-374 of actin through the maleimide moiety. In the presence of micromolar [Ca2+], the major cross-linked
Mayumi Tamura et al.
Biochemical and biophysical research communications, 390(3), 581-584 (2009-10-13)
Relatively weak interactions between galectins and their potential ligands can hinder identification of physiological lectin ligands using conventional methods such as affinity purification. We have employed a combination of cysteine mutagenesis with chemical crosslinking using a photoactivatable sulfhydryl reagent benzophenone-4-maleimide
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