方案
99%
沸点
325-330 °C (lit.)
mp
118-120 °C (lit.)
SMILES字符串
C1CCc2c(C1)[nH]c3ccccc23
InChI
1S/C12H13N/c1-3-7-11-9(5-1)10-6-2-4-8-12(10)13-11/h1,3,5,7,13H,2,4,6,8H2
InChI key
XKLNOVWDVMWTOB-UHFFFAOYSA-N
应用
1,2,3,4-四氢咔唑可作为起始材料：
- 通过光氧化反应制备螺[环戊烷-1,2′-吲哚啉-3′-酮]。
- 通过N-酰基化反应制备9-酰基-1,2,3,4-四氢咔唑。
- 通过钯催化的不对称加氢反应制备咔唑。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Xu-Fan Wang et al.
Organic letters, 12(5), 1140-1143 (2010-02-12)
A hydrogen bonding-mediated double Michael addition-aromatization cascade of 2-propenylindoles and nitroolefins has been disclosed. The methodology allows an efficient synthesis of diverse and structurally complex tetrahydrocarbazoles in good to excellent enantioselectivities and diastereoselectivities.
Synthesis of novel 1-substituted and 1, 9-disubstituted-1, 2, 3, 4-tetrahydro-9H-carbazole derivatives as potential anticancer agents
Shmeiss NAMM, et al.
Molecules (Basel), 5(10), 1101-1112 (2000)
P Crawford et al.
The Journal of chemical physics, 128(10), 105104-105104 (2008-03-19)
The carbazole moiety is a component of many important pharmaceuticals including anticancer and anti-HIV agents and is commonly utilized in the production of modern polymeric materials with novel photophysical and electronic properties. Simple carbazoles are generally produced via the aromatization
Uma Siripurapu et al.
Bioorganic & medicinal chemistry letters, 16(14), 3793-3796 (2006-05-20)
Comparison of several amine-substituted and methoxy-substituted analogs of N1-(4-aminobenzene)sulfonylindole suggests that these substituents might contribute to the 5-HT6 serotonin receptor affinity of these agents via their electronic effect on the indolic nucleus. Their 1,2,3,4-tetrahydrocarbazole counterparts behave differently.
Subhasish Neogi et al.
Journal of combinatorial chemistry, 12(5), 617-629 (2010-07-01)
The one-pot synthesis of a new substituted 1,2,3,4-tetrahydrocarbazoles has been described via Petasis reactions. These tetrahydrocarbazoles exhibits various medicinal importance and might be suitable for elaboration into larger peptides at carboxy termini. The scope and limitations of this method have
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