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Merck
CN

790304P

Avanti

Coag Reagent I

Avanti Research - A Croda Brand

别名:

Coag Reagent, Coagulation Reagent I, contains DOPE:DOPS:DOPC (5:3:2 w/w)

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UNSPSC Code:
12352211
NACRES:
NA.25
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产品名称

Coag Reagent I, Avanti Research - A Croda Brand

packaging

pkg of 2 × 100 mg (790304P-200mg), pkg of 1 × 25 mg (790304P-25mg)

manufacturer/tradename

Avanti Research - A Croda Brand

application(s)

microbiology

lipid type

phospholipids

shipped in

dry ice

storage temp.

−20°C

form

powder

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General description

Coag Reagent I comprises 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine(DOPE), 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) in the ratio 5:3:2 w/w. They are present predominantly in the synaptic vesicle membrane. DOPC has choline group and DOPE comprises ethanolamine moiety. At neutral pH, DOPE and DOPC exist as a zwitterion whereas DOPS takes up a negative charge and has a serine group.

Application

Coag Reagent I has been used in the preparation of small unilamellar vesicles (SUVs) for α-synuclein binding studies. It may be used in the preparation of bilayers for reconstituting ryanodine receptor type 2 (RyR2) for single-channel recording studies. It may be used for glass supported lipid bilayers preparation.

Biochem/physiol Actions

Coag Reagent I mixed lipid is useful in the preparation of supported lipid bilayers and platelet membranes for coagulation studies. It is used in the small unilamellar vesicles (SUVs) generation for α-synuclein and squalamine binding studies.

Packaging

5 mL Clear Glass Sealed Ampule (790304P-200mg)
5 mL Clear Glass Sealed Ampule (790304P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

No data available

flash_point_c

No data available


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分析证书(COA)

Lot/Batch Number

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A natural product inhibits the initiation of alpha-synuclein aggregation and suppresses its toxicity
Perni M, et al.
Proceedings of the National Academy of Sciences of the USA, 114(6), E1009-E1017 (2017)
EL20, a potent antiarrhythmic compound, selectively inhibits calmodulin-deficient ryanodine receptor type 2
Klipp RC, et al.
Heart Rhythm : the Official Journal of the Heart Rhythm Society, 15(4), 578-586 (2018)
A M van den Besselaar et al.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 4(6), 895-903 (1993-12-01)
The activated partial thromboplastin time (aPTT) is the most popular test for monitoring of heparin therapy. The purpose of the present study was to show that an aPTT reagent with good response to heparin can be prepared from synthetic phosphoglycerides.
Nuclear magnetic resonance observation of ?-synuclein membrane interaction by monitoring the acetylation reactivity of its lysine side chains
Lee JH, et al.
Biochemistry, 55(35), 4949-4959 (2016)
Three-Dimensional Heterogeneous Structure Formation on a Supported Lipid Bilayer Disclosed by Single-Particle Tracking
Zhong Y & Wang G
Langmuir, 34(39), 11857-11865 (2018)

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