产品名称
Coag Reagent I, Avanti Research™ - A Croda Brand
packaging
pkg of 2 × 100 mg (790304P-200mg), pkg of 1 × 25 mg (790304P-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
application(s)
microbiology
lipid type
phospholipids
shipped in
dry ice
storage temp.
−20°C
form
powder
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General description
Coag Reagent I comprises 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine(DOPE), 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) in the ratio 5:3:2 w/w. They are present predominantly in the synaptic vesicle membrane. DOPC has choline group and DOPE comprises ethanolamine moiety. At neutral pH, DOPE and DOPC exist as a zwitterion whereas DOPS takes up a negative charge and has a serine group.
Application
Coag Reagent I has been used in the preparation of small unilamellar vesicles (SUVs) for α-synuclein binding studies. It may be used in the preparation of bilayers for reconstituting ryanodine receptor type 2 (RyR2) for single-channel recording studies. It may be used for glass supported lipid bilayers preparation.
Biochem/physiol Actions
Coag Reagent I mixed lipid is useful in the preparation of supported lipid bilayers and platelet membranes for coagulation studies. It is used in the small unilamellar vesicles (SUVs) generation for α-synuclein and squalamine binding studies.
Packaging
5 mL Clear Glass Sealed Ampule (790304P-200mg)
5 mL Clear Glass Sealed Ampule (790304P-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
EL20, a potent antiarrhythmic compound, selectively inhibits calmodulin-deficient ryanodine receptor type 2
Klipp RC, et al.
Heart Rhythm : the Official Journal of the Heart Rhythm Society, 15(4), 578-586 (2018)
A natural product inhibits the initiation of alpha-synuclein aggregation and suppresses its toxicity
Perni M, et al.
Proceedings of the National Academy of Sciences of the USA, 114(6), E1009-E1017 (2017)
Three-Dimensional Heterogeneous Structure Formation on a Supported Lipid Bilayer Disclosed by Single-Particle Tracking
Zhong Y & Wang G
Langmuir, 34(39), 11857-11865 (2018)
A M van den Besselaar et al.
Clinical chemistry, 43(7), 1215-1222 (1997-07-01)
To contribute to the development of a reference reagent for monitoring heparin therapy, a lyophilized partial thromboplastin time (PTT) reagent was prepared from synthetic dioleoylphosphatidylcholine, dioleoylphosphatidylserine, and dioleoylphosphatidylethanolamine, with colloidal silica as activator. The reagent, coded 91/558, was contained in
Yaning Zhong et al.
Langmuir : the ACS journal of surfaces and colloids, 34(39), 11857-11865 (2018-09-02)
Three-dimensional (3D) single-particle tracking was employed to study the lipid membrane morphology change at different pHs on glass supported lipid bilayers (SLBs) [1,2-dioleoyl- sn-glycero-3-phosphoethanolamine/1,2-dioleoyl- sn-glycero-3-phospho-l-serine (sodium salt)/1,2-dioleoyl- sn-glycero-3-phosphocholine = 5:3:2]. Fluorescently tagged, carboxylated polystyrene nanoparticles (of 100 nm) were used
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