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经验公式（希尔记法）:
C31H54N5O11P
化学文摘社编号:
分子量:
703.76
MDL number:
NACRES:
NA.25
UNSPSC Code:
12352211
产品名称
16:0-06:0 NBD PA, Avanti Research™ - A Croda Brand 810173P, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (810173P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810173P
shipped in
dry ice
storage temp.
−20°C
Application
16:0-06:0 NBD PA 1-palmitoyl-2-{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl}-sn-glycero-3-phosphate is suitable to measure the substrate transport by an increase in cellular fluorescence to determine type 4 P-type ATPases (P4-ATPase) discrimination and its glycerophospholipid (GPL) substrate selection through the directed evolution of a sphingomyelin (SM) flippase.
Biochem/physiol Actions
Phosphatidic acid (PA) is crucial for intracellular signaling involved various cellular processes including membrane trafficking and sperm hyper-activation. It plays a vital role in lipid synthesis.
General description
Phosphatidic acid (PA) is a simple anionic membrane phospholipid. The phospholipid contains phosphomonoester polar head group and two long hydrophobic acyl chains. 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) PA is a fluorescent analog with 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) attached to the sn-2 fatty acid of PA.
Packaging
5 mL Amber Glass Screw Cap Vial (810173P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
Phosphatidic acid binding proteins display differential binding as a function of membrane curvature stress and chemical properties
Putta P, et al.
Biochimica et Biophysica Acta, 1858(11), 2709-2716 (2016)
Priya Putta et al.
Biochimica et biophysica acta, 1858(11), 2709-2716 (2016-08-03)
Phosphatidic acid (PA) is a crucial membrane phospholipid involved in de novo lipid synthesis and numerous intracellular signaling cascades. The signaling function of PA is mediated by peripheral membrane proteins that specifically recognize PA. While numerous PA-binding proteins are known
Phosphatidic acid in membrane rearrangements
Zhukovsky MA, et al.
Febs Letters, 593(17), 2428-2451 (2019)
Mikhail A Zhukovsky et al.
FEBS letters, 593(17), 2428-2451 (2019-08-01)
Phosphatidic acid (PA) is the simplest cellular glycerophospholipid characterized by unique biophysical properties: a small headgroup; negative charge; and a phosphomonoester group. Upon interaction with lysine or arginine, PA charge increases from -1 to -2 and this change stabilizes protein-lipid
A Chauhan et al.
Neurochemical research, 25(3), 423-429 (2000-04-13)
Fibrillar amyloid beta-protein (Abeta) is the major protein of amyloid plaques in the brains of patients with Alzheimer's disease (AD). The mechanism by which normally produced soluble Abeta gets fibrillized in AD is not clear. We studied the effect of
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