产品名称
C12-NBD Galactosyl Ceramide, Avanti Research™ - A Croda Brand 810221P, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 250 μg (810221P-250ug)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810221P
shipped in
dry ice
storage temp.
−20°C
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General description
C12-NBD Galactosyl Ceramide is a fluorescent derivative of biologically active compound galactosyl ceramide. NBD (2-(4-nitro-2,1,3-benzoxadiazol-7-yl) aminoethyl) is a fluorophore. Galactosyl ceramide (Galactocerebroside) is a glycosphingolipid that is synthesized in the lumen of the endoplasmic reticulum.
Application
C12-NBD Galactosyl Ceramide may be used as a substrate in biochemical characterization of ceramidase analogue expressed in Aspergillus oryzae.
Biochem/physiol Actions
Galactosyl Ceramide is a precursor of 3′-sulfo-galactosylceramide which is a major sulfoglycolipid present in the brain and other organ systems. It is also a necessary component in differentiation of oligodendrocytes. The abnormal accumulation of galactosyl ceramide is associated with Fabry′s disease and Krabbe′s disease.
Packaging
5 mL Amber Glass Screw Cap Vial (810221P-250ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
法规信息
新产品
此项目有
Characterization of a neutral ceramidase orthologue from Aspergillus oryzae
Fluorescent and Luminescent Probes for Biological Activity, 298(2), 157-165 (1999)
Heike Schulze et al.
Cold Spring Harbor perspectives in biology, 3(6) (2011-04-20)
Lysosomal lipid storage diseases, or lipidoses, are inherited metabolic disorders in which typically lipids accumulate in cells and tissues. Complex lipids, such as glycosphingolipids, are constitutively degraded within the endolysosomal system by soluble hydrolytic enzymes with the help of lipid
Yanfeng Chen et al.
Neuromolecular medicine, 12(4), 306-319 (2010-08-04)
Sphingolipids (SP) are a complex class of molecules found in essentially all eukaryotes and some prokaryotes and viruses where they influence membrane structure, intracellular signaling, and interactions with the extracellular environment. Because of the combinatorial nature of their biosynthesis, there
Galactocerebroside is a specific cell-surface antigenic marker for oligodendrocytes in culture.
M C Raff et al.
Nature, 274(5673), 813-816 (1978-08-24)
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