产品名称
C6-NBD Lactosyl Ceramide, Avanti Research™ - A Croda Brand 810226C
assay
>99% (TLC)
form
liquid
packaging
pkg of 1 × 1 mL (810226C-250ug)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810226C
concentration
0.25 mg/mL (810226C-250ug)
shipped in
dry ice
storage temp.
−20°C
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General description
C6-NBD Lactosyl ceramide is a fluorescent derivative of biologically active compound lactosyl ceramide. Lactosyl ceramide is a glycosphingolipid that is present on neutrophils and macrophages.
Application
C6-NBD Lactosyl ceramide may be used for phospholipid labeling and fluorescence-lifetime imaging microscopy (FILM) with respect to cell membranes.
Biochem/physiol Actions
Lactosyl ceramide is a precursor of various glycosphingolipids like oligoglycosylceramides and gangliosides involved in various vital cellular processes. It plays a major role in signaling cascades leading to phenotypic changes such as adhesion, migration, cell proliferation and angiogenesis. Lactosyl ceramide is a crucial molecule involved in osteoclastogenesis mediated by macrophage-colony stimulating factor.
Packaging
5 mL Amber Glass Screw Cap Vial (810226C-250ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
signalword
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
target_organs
Central nervous system
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
does not flash
flash_point_c
does not flash
法规信息
新产品
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T Iwamoto et al.
The Journal of biological chemistry, 276(49), 46031-46038 (2001-10-11)
Glycosphingolipids and their metabolites play important roles in a variety of biological processes. Several signal molecules are localized in a glycolipid-enriched microdomain on the cell surface, and their signals are regulated by the glycolipid composition. However, the function of glycolipids
Ana Zarubica et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 23(6), 1775-1785 (2009-01-20)
The ABCA1 transporter orchestrates cellular lipid homeostasis by promoting the release of cholesterol to plasmatic acceptors. The molecular mechanism is, however, unknown. We report here on the biophysical analysis in living HeLa cells of the ABCA1 lipid microenvironment at the
W I Weis et al.
Annual review of biochemistry, 65, 441-473 (1996-01-01)
Lectins are responsible for cell surface sugar recognition in bacteria, animals, and plants. Examples include bacterial toxins; animal receptors that mediate cell-cell interactions, uptake of glycoconjugates, and pathogen neutralization; and plant toxins and mitogens. The structural basis for selective sugar
S Hakomori et al.
Journal of biochemistry, 118(6), 1091-1103 (1995-12-01)
Glycosphingolipids (GSLs), cell type-specific markers which change dramatically during ontogenesis and oncogenesis, have been implicated as playing major roles in cellular interactions and control of cell proliferation in multicellular organisms. These functional roles have been partially clarified through two types
F Pincet et al.
Biophysical journal, 80(3), 1354-1358 (2001-02-27)
Carbohydrate-carbohydrate interactions are rarely considered in biologically relevant situations such as cell recognition and adhesion. One Ca(2+)-mediated homotypic interaction between two Lewis(x) determinants (Le(x)) has been proposed to drive cell adhesion in murine embryogenesis. Here, we confirm the existence of
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