810226C
Avanti
C6-NBD Lactosyl Ceramide
Avanti Research™ - A Croda Brand
别名:
N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-lactosyl-β1-1′-sphingosine
产品名称
C6-NBD Lactosyl Ceramide, Avanti Research™ - A Croda Brand 810226C
方案
>99% (TLC)
表单
liquid
包装
pkg of 1 × 1 mL (810226C-250ug)
制造商/商品名称
Avanti Research™ - A Croda Brand 810226C
浓度
0.25 mg/mL (810226C-250ug)
运输
dry ice
储存温度
−20°C
一般描述
C6-NBD Lactosyl ceramide is a fluorescent derivative of biologically active compound lactosyl ceramide. Lactosyl ceramide is a glycosphingolipid that is present on neutrophils and macrophages.
应用
C6-NBD Lactosyl ceramide may be used for phospholipid labeling and fluorescence-lifetime imaging microscopy (FILM) with respect to cell membranes.
生化/生理作用
Lactosyl ceramide is a precursor of various glycosphingolipids like oligoglycosylceramides and gangliosides involved in various vital cellular processes. It plays a major role in signaling cascades leading to phenotypic changes such as adhesion, migration, cell proliferation and angiogenesis. Lactosyl ceramide is a crucial molecule involved in osteoclastogenesis mediated by macrophage-colony stimulating factor.
包装
5 mL Amber Glass Screw Cap Vial (810226C-250ug)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
警示用语：
Danger
危险分类
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
靶器官
Central nervous system
储存分类代码
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 3
闪点(°F)
does not flash
闪点(°C)
does not flash
法规信息
新产品
此项目有
Ana Zarubica et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 23(6), 1775-1785 (2009-01-20)
The ABCA1 transporter orchestrates cellular lipid homeostasis by promoting the release of cholesterol to plasmatic acceptors. The molecular mechanism is, however, unknown. We report here on the biophysical analysis in living HeLa cells of the ABCA1 lipid microenvironment at the
T Iwamoto et al.
The Journal of biological chemistry, 276(49), 46031-46038 (2001-10-11)
Glycosphingolipids and their metabolites play important roles in a variety of biological processes. Several signal molecules are localized in a glycolipid-enriched microdomain on the cell surface, and their signals are regulated by the glycolipid composition. However, the function of glycolipids
Subroto Chatterjee et al.
Biochimica et biophysica acta, 1780(3), 370-382 (2007-12-14)
Although lactosylceramide (LacCer) plays a pivotal role in the biosynthesis of nearly all the major glycosphingolipids, its function in regulating cellular function has begun to emerge only recently. Our current opinion is that several physiologically critical molecules such as modified/oxidized
F Pincet et al.
Biophysical journal, 80(3), 1354-1358 (2001-02-27)
Carbohydrate-carbohydrate interactions are rarely considered in biologically relevant situations such as cell recognition and adhesion. One Ca(2+)-mediated homotypic interaction between two Lewis(x) determinants (Le(x)) has been proposed to drive cell adhesion in murine embryogenesis. Here, we confirm the existence of
S Hakomori et al.
Journal of biochemistry, 118(6), 1091-1103 (1995-12-01)
Glycosphingolipids (GSLs), cell type-specific markers which change dramatically during ontogenesis and oncogenesis, have been implicated as playing major roles in cellular interactions and control of cell proliferation in multicellular organisms. These functional roles have been partially clarified through two types
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