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Merck
CN

840022C

Avanti

Brain PE

Avanti Research™ - A Croda Brand

别名:

L-α-phosphatidylethanolamine (Brain, Porcine)

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关于此项目

化学文摘社编号:
383907-18-4
UNSPSC Code:
12352211
NACRES:
NA.25

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产品名称

Brain PE, Avanti Research™ - A Croda Brand 840022C

SMILES string

[H][C@@](COP([O-])(OCC[NH3+])=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O

InChI

1S/C41H80NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h18,20,39H,3-17,19,21-38,42H2,1-2H3,(H,45,46)/b20-18-/t39-/m1/s1

InChI key

JQKOHRZNEOQNJE-DJEJVYNPSA-N

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (840022C-25mg)
pkg of 2 × 4 mL (840022C-200mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 840022C

concentration

10 mg/mL (840022C-25mg)
25 mg/mL (840022C-200mg)

lipid type

phosphoglycerides

shipped in

dry ice

storage temp.

−20°C

Application

Brain PE has been used as a cofactor to support the replication of highly infectious prion protein (PrPSc). It has also been used for the preparation of liposomes.

General description

Contains ~50% plasmalogen ether lipid

Packaging

5 mL Clear Glass Sealed Ampule (840022C-200mg)
5 mL Clear Glass Sealed Ampule (840022C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

存储类别

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

法规信息

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分析证书(COA)

Lot/Batch Number

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Contrasting effects of two lipid cofactors of prion replication on the conformation of the prion protein
Srivastava S and Baskakov IV
Testing, 10(6), e0130283-e0130283 (2015)
Preserving prion strain identity upon replication of prions in vitro using recombinant prion protein
Makarava N, et al.
Acta Neuropathologica Communications, 6(1), 92-92 (2018)
Saurabh Srivastava et al.
PloS one, 10(6), e0130283-e0130283 (2015-06-20)
Recent studies introduced two experimental protocols for converting full-length recombinant prion protein (rPrP) purified from E.coli into the infectious prion state (PrPSc) with high infectivity titers. Both protocols employed protein misfolding cyclic amplification (PMCA) for generating PrPSc de novo, but
Arupratan Das et al.
Nature cell biology, 14(3), 304-310 (2012-02-22)
Lipid asymmetry at the plasma membrane is essential for such processes as cell polarity, cytokinesis and phagocytosis. Here we find that a lipid flippase complex, composed of Lem3, Dnf1 or Dnf2, has a role in the dynamic recycling of the
Gillian L Dornan et al.
Structure (London, England : 1993), 28(2), 145-156 (2019-12-14)
The class I phosphoinositide 3-kinases (PI3Ks) are key signaling enzymes composed of a heterodimer of a p110 catalytic subunit and a p85 regulatory subunit, with PI3K mutations being causative of multiple human diseases including cancer, primary immunodeficiencies, and developmental disorders.
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