产品名称
VPC 44116, Avanti Research™ - A Croda Brand 857346P, powder
SMILES string
CCCCCCCCC1=CC(NC([C@H](N)CCP(O)(O)=O)=O)=CC=C1
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (857346P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 857346P
lipid type
cardiolipins
sphingolipids
shipped in
dry ice
storage temp.
−20°C
General description
除了受体选择性激动剂（例如 SEW2871）外，竞争性 S1P 受体拮抗剂还可用于研究 S1P 信号传导（特别是涉及 S1P1 信号传导）的生理效应。（R）-3-氨基-（3-辛基苯基氨基）-4-氧代丁基膦酸（VPC44116）（S1P1/3 拮抗剂）和类似物（R）-3-氨基-（3-己基苯基氨基）-4-氧代丁基膦酸（ W146）（S1P1 拮抗剂），通过在小鼠肺组织中进行伊文思蓝染料渗漏检测发现两者均可增加毛细血管的通透性。该产品受专利号 US 7,888,527 B2 的保护。Avanti 经弗吉尼亚大学许可制造
Packaging
5 mL 琥珀色玻璃螺旋盖小瓶（857346P-1mg）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
13 - Non Combustible Solids
wgk
WGK 3
Perry C Kennedy et al.
The Journal of pharmacology and experimental therapeutics, 338(3), 879-889 (2011-06-03)
Sphingosine 1-phosphate (S1P) is a phospholipid that binds to a set of G protein-coupled receptors (S1P(1)-S1P(5)) to initiate an array of signaling cascades that affect cell survival, differentiation, proliferation, and migration. On a larger physiological scale, the effects of S1P
Frank W Foss et al.
Bioorganic & medicinal chemistry, 15(2), 663-677 (2006-11-23)
The synthesis of N-arylamide phosphonates and related arylether and arylamine analogues provided potent, subtype-selective agonists and antagonists of the five known sphingosine 1-phosphate (S1P) receptors (S1P(1-5)). To this end, the syntheses of phosphoserine mimetics-selectively protected and optically active phosphonoserines-are described.
Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists.
Foss FW Jr, et al.
Bioorganic & Medicinal Chemistry, 15, 663-677 (2007)
Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo.
Sanna MG, et al.
Nature Chemical Biology, 2, 434-441 (2006)
Vijay Avin Balaji Ragunathrao et al.
Cell reports, 29(11), 3472-3487 (2019-12-12)
The vascular endothelial growth factor-A (VEGF-A)-VEGFR2 pathway drives tumor vascularization by activating proangiogenic signaling in endothelial cells (ECs). Here, we show that EC-sphingosine-1-phosphate receptor 1 (S1PR1) amplifies VEGFR2-mediated angiogenic signaling to enhance tumor growth. We show that cancer cells induce
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