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经验公式（希尔记法）:
C18H40NO5P
化学文摘社编号:
分子量:
381.49
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
产品名称
Sphinganine-1-Phosphate (d18:0), Avanti Research™ - A Croda Brand 860536P, powder
SMILES string
[H][C@](CCCCCCCCCCCCCCC)(O)[C@]([NH3+])([H])COP([O-])(O)=O
InChI
1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/t17-,18+/m0/s1
InChI key
YHEDRJPUIRMZMP-ZWKOTPCHSA-N
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (860536P-1mg), pkg of 1 × 5 mg (860536P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860536P
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
General description
Sphinganine-1-Phosphate (SA1P) is a bioactive lipid present in mammals. It is produced from the sphingoid base, sphinganine in the presence of sphingosine kinase (SPHK).
Application
Sphinganine-1-Phosphate (d18:0) has been used as a reference standard in ultra performance liquid chromatography coupled to a mass spectrometry. It is suitable for use as an internal standard for ultra high performance liquid chromatography for the quantification of blood and muscle sphingolipid. Sphinganine-1-phosphate (d18:0) is also suitable for use as standard in liquid chromatography tandem mass spectrometry.
Biochem/physiol Actions
Sphinganine-1-Phosphate (SA1P) is an important marker for cancer and immune system disorders studies. It elicits protective functionality in hepatic ischemia. Elevated levels of SA1P is observed in hepatocellular carcinoma.
Packaging
5 mL Amber Glass Screw Cap Vial (860536P-1mg)
5 mL Amber Glass Screw Cap Vial (860536P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Exercise increases sphingoid base-1-phosphate levels in human blood and skeletal muscle in a time-and intensity-dependent manner
Baranowski M, et al.
European Journal of Applied Physiology, 115(5), 993-1003 (2015)
Serum sphingolipidomic analyses reveal an upregulation of C16-ceramide and sphingosine-1-phosphate in hepatocellular carcinoma
Grammatikos G, et al.
Testing, 7(14), 18095-18095 (2016)
Metabolomic insights into system-wide coordination of vertebrate metamorphosis
Ichu T, et al.
BMC Developmental Biology, 14(1), 5-5 (2014)
Accurate quantification of sphingosine-1-phosphate in normal and Fabry disease plasma, cells and tissues by LC-MS/MS with 13C-encoded natural S1P as internal standard
Mirzaian M, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 459(5), 36-44 (2016)
Katja Jakobi et al.
International journal of molecular sciences, 21(7) (2020-04-05)
Hepatocellular carcinoma (HCC) shows a remarkable heterogeneity and is recognized as a chemoresistant tumor with dismal prognosis. In previous studies, we observed significant alterations in the serum sphingolipids of patients with HCC. This study aimed to investigate the in vitro
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