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经验公式（希尔记法）:
C42H83NO3
化学文摘社编号:
分子量:
650.11
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
产品名称
C24:1 Dihydroceramide (d18:0/24:1(15Z)), Avanti Research™ - A Croda Brand 860629P, powder
SMILES string
OC[C@]([H])(NC(CCCCCCCCCCCCC/C=C\CCCCCCCC)=O)[C@]([H])(O)CCCCCCCCCCCCCCC
InChI
1S/C42H83NO3/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-26-28-30-32-34-36-38-42(46)43-40(39-44)41(45)37-35-33-31-29-27-25-16-14-12-10-8-6-4-2/h17-18,40-41,44-45H,3-16,19-39H2,1-2H3,(H,43,46)/b18-17-/t40-,41+/m0/s1
InChI key
YUULKFVZRXQHPM-ATHUGRIKSA-N
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 5 mg (860629P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860629P
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
Application
C24:1 Dihydroceramide has been used as a standard in quadrupole time-of-flight (Q-TOF) mass spectrometry for the measurement of sphingolipid metabolites in adipose tissue. It has also been used a standard in diacylglycerol kinase (DGK) assay to quantify dihydroceramides in CLN9-deficient cells.
Biochem/physiol Actions
C24:1 Dihydroceramide is a synthetic dihydroceramide. Dihydroceramides are reduced to ceramides by the enzyme dihydroceramide desaturase. Elevated levels of serum 24:1 DHC has been observed in patients with history of hepatocellular carcinoma (HCC) pre-orthopic liver transplantation (OLT), compared to patients with no prior HCC. Therefore, 24:1 DHC can be used as a HCC biomarker in post-OLT patients.
Packaging
5 mL Amber Glass Screw Cap Vial (860629P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
C22: 0-and C24: 0-dihydroceramides confer mixed cytotoxicity in T-cell acute lymphoblastic leukemia cell lines
Holliday Jr, et al.
Testing, 8(9) (2013)
The CLN9 protein, a regulator of dihydroceramide synthase
Schulz A, et al.
The Journal of Biological Chemistry, 281(5), 2784-2794 (2006)
C22: 0-and C24: 0-dihydroceramides confer mixed cytotoxicity in T-cell acute lymphoblastic leukemia cell lines
Holliday Jr, et al.
PLoS ONE, 8(9) (2013)
Michael W Holliday et al.
PloS one, 8(9), e74768-e74768 (2013-09-17)
We previously reported that fenretinide (4-HPR) was cytotoxic to acute lymphoblastic leukemia (ALL) cell lines in vitro in association with increased levels of de novo synthesized dihydroceramides, the immediate precursors of ceramides. However, the cytotoxic potentials of native dihydroceramides have
Angela Schulz et al.
The Journal of biological chemistry, 281(5), 2784-2794 (2005-11-24)
A new variant of a group of pediatric neurodegenerative diseases known as neuronal ceroid lipofuscinosis (NCL) or Batten disease has been identified. It is termed CLN9-deficient. CLN9-deficient fibroblasts have a distinctive phenotype of rapid growth and increased apoptosis and diminished
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