产品名称
C18 Ceramide (d17:1/18:0), Avanti Research™ - A Croda Brand 860646P, powder
InChI key
KGEXFGDEDXQZLQ-QKSCFGQVSA-N
SMILES string
OC[C@]([H])(NC(CCCCCCCCCCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCC
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 10 mg (860646P-10mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860646P
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
General description
Ceramide is a bioactive sphingolipid. C18 Ceramide (d17:1/18:0) is synthesized by the N-acylation of sphingosine. This reaction is catalyzed by ceramide synthase 1 (CerS1). C18 Ceramide is highly expressed in brain tissues.
Application
C18 Ceramide (d17:1/18:0) has been used as an internal standard in mass spectrometer and ultra high performance Liquid Chromatography for quantitative measurement of ceramides in muscle.
Biochem/physiol Actions
C18 Ceramide has an ability to induce cell death. Defects in the generation or accumulation of C18 Ceramide has been associated with the development of human head and neck squamous cell carcinomas (HNSCC).
Packaging
5 mL Amber Glass Screw Cap Vial (860646P-10mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Long-term follow-up of muscle lipid accumulation, mitochondrial activity and oxidative stress and their relationship with impaired glucose homeostasis in high fat high fructose diet-fed rats
Wang Y, et al.
The Journal of Nutritional Biochemistry, 64(5), 182-197 (2019)
Diverse functions of ceramide in cancer cell death and proliferation
Advances in Cancer Research, 117, 37-58 (2013)
Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C18-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis
Karahatay S, et al.
Cancer Letters, 256(1), 101-111 (2007)
Koichi Ishida et al.
The Journal of investigative dermatology (2020-02-06)
Little is known about the pathophysiological linkages between altered ceramide profiles in the stratum corneum (SC) of patients with atopic dermatitis and their impaired skin barrier and water-holding functions. We studied those characteristics following topical treatment with a designed synthetic
The structure of D-erythro-C18 ceramide at the air-water interface
Vaknin D and Kelley MS
Biophysical Journal, 79(5), 2616-2623 (2000)
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