产品名称
C16:0 Ceramide (d18:2(4E,8Z)/16:0), Avanti Research™ - A Croda Brand 860692P, powder
InChI
1S/C34H65NO3/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-33(37)32(31-36)35-34(38)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h19,21,27,29,32-33,36-37H,3-18,20,22-26,28,30-31H2,1-2H3,(H,35,38)/b21-19-,29-27+/t32-,33+/m0/s1
InChI key
GMWIWVUTMCBDSP-JXXPSAROSA-N
SMILES string
OC[C@@](NC(CCCCCCCCCCCCCCC)=O)([H])[C@]([H])(O)/C=C/CC/C=C\CCCCCCCCC
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (860692P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860692P
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
General description
C16:0 Ceramide (d18:2(4E,8Z)/16:0) or N-palmitoyl-D-erythro-sphingosine (d18:2(4E,8Z) base) is a long chain ceramide derived from sphingosine containing two double bonds with palmitic acid. C16:0 Ceramide synthesis is catalyzed by the enzyme ceramide synthase 6 (CerS6).
Biochem/physiol Actions
C16:0-ceramide facilitates obesity-related insulin resistance. It exhibits pro-apoptotic function. Elevated levels of C16:0-ceramide has been observed in adipose tissue of obese patients.
Packaging
5 mL Amber Glass Screw Cap Vial (860692P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
Sarah M Turpin et al.
Cell metabolism, 20(4), 678-686 (2014-10-09)
Ceramides increase during obesity and promote insulin resistance. Ceramides vary in acyl-chain lengths from C14:0 to C30:0 and are synthesized by six ceramide synthase enzymes (CerS1-6). It remains unresolved whether obesity-associated alterations of specific CerSs and their defined acyl-chain length
Timothy Hla et al.
Cell metabolism, 20(5), 703-705 (2014-12-03)
A substantive literature has accumulated implicating sphingolipids, in particular ceramides, as mediators of insulin resistance in metabolic syndrome. Thanks to recent technical advances in mouse genetics and lipidomics, two independent laboratories identify the same sphingolipid, C16:0-ceramide, as principal mediator of obesity-related
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持