870601P
Avanti
Azelaoyl-PAF
Avanti Research™ - A Croda Brand
别名:
1-hexadecyl-2-azelaoyl-sn-glycero-3-phosphocholine
产品名称
Azelaoyl-PAF, Avanti Research™ - A Croda Brand 870601P, powder
方案
>99% (TLC)
表单
powder
包装
pkg of 1 × 1 mg (870601P-1mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 870601P
运输
dry ice
储存温度
−20°C
SMILES字符串
[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCC(O)=O)=O)COCCCCCCCCCCCCCCCC)=O
InChI
1S/C33H66NO9P/c1-5-6-7-8-9-10-11-12-13-14-15-16-20-23-27-40-29-31(30-42-44(38,39)41-28-26-34(2,3)4)43-33(37)25-22-19-17-18-21-24-32(35)36/h31H,5-30H2,1-4H3,(H-,35,36,38,39)/t31-/m1/s1
InChI key
ZDFOCDTXDPKJKA-WJOKGBTCSA-N
应用
Azelaoyl-PAF may be used to study its binding affinity with 4F or 2F anti-inflammatory peptides.
生化/生理作用
Azelaoyl-PAF (1-hexadecyl-2-azelaoyl-sn-glycero-3-phosphocholine) is a low molecular weight alkyl phosphatidylcholine. It is a constituent of the lipid pool within oxidized low-density lipoprotein (oxLDL) particles. Azelaoyl-PAF serves as a high affinity ligand and agonist for peroxisome proliferator-activated receptor-γ (PPARγ).
包装
5 mL Clear Glass Sealed Ampule (870601P-1mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
Raquel F Epand et al.
Biochimica et biophysica acta, 1788(9), 1967-1975 (2009-06-30)
The peptide 4F is known to have potent anti-atherogenic activity. 4F is an 18 residue peptide that has a sequence capable of forming a class A amphipathic helix. Several other class A amphipathic helical, 18 residue peptides with the same
P Tontonoz et al.
Cell, 93(2), 241-252 (1998-05-06)
The formation of foam cells from macrophages in the arterial wall is characterized by dramatic changes in lipid metabolism, including increased expression of scavenger receptors and the uptake of oxidized low-density lipoprotein (oxLDL). We demonstrate here that the nuclear receptor
S S Davies et al.
The Journal of biological chemistry, 276(19), 16015-16023 (2001-03-30)
Synthetic high affinity peroxisome proliferator-activated receptor (PPAR) agonists are known, but biologic ligands are of low affinity. Oxidized low density lipoprotein (oxLDL) is inflammatory and signals through PPARs. We showed, by phospholipase A(1) digestion, that PPARgamma agonists in oxLDL arise
Douglas S Watson et al.
Vaccine, 27(34), 4672-4683 (2009-06-13)
The membrane proximal region (MPR) of HIV-1 gp41 is a desirable target for development of a vaccine that elicits neutralizing antibodies since the patient-derived monoclonal antibodies, 2F5 and 4E10, bind to the MPR and neutralize primary HIV isolates. The 2F5
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