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关于此项目
经验公式（希尔记法）:
C11H22O3
化学文摘社编号:
分子量:
202.29
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
产品名称
4-HNE-二甲基缩醛, Avanti Research™ - A Croda Brand 870608H, hexane solution
InChI key
ATGIHMSJAARJTF-AAXQSMANSA-N
SMILES string
CCCCC[C@@H](O)/C=C/C(OC)OC
assay
>99% (TLC)
form
hexane solution
packaging
pkg of 1 × 1 mL (870608H-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 870608H
concentration
6.8 mg/mL (870608H-5mg)
lipid type
phosphoglycerides
bioactive lipids
shipped in
dry ice
storage temp.
−20°C
General description
4-羟基壬烯醛（4-HNE或HNE）是细胞内脂质过氧化产生的α,β-不饱和羟基烯醛。一些研究人员假设，4-HNE在从细胞周期事件到细胞粘附的多种途径中的细胞信号转导中发挥关键作用。
二甲基缩醛衍生物是更稳定的4-HNE形式，有利于化合物在使用过程中的长期保存。在酸存在下，很容易转化为4-HNE。
二甲基缩醛衍生物是更稳定的4-HNE形式，有利于化合物在使用过程中的长期保存。在酸存在下，很容易转化为4-HNE。
Packaging
2mL棕色玻璃密封安瓿（870608H-5mg）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Disclaimer
Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.
signalword
Danger
Hazard Classifications
Aquatic Chronic 2 - Asp. Tox. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Inhalation - STOT SE 3
target_organs
Central nervous system, Nervous system
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
-14.8 °F - closed cup
flash_point_c
-26.0 °C - closed cup
法规信息
危险化学品
此项目有
Rajendra Sharma et al.
European journal of biochemistry, 271(9), 1690-1701 (2004-04-21)
4-Hydroxy-2-trans-nonenal (4-HNE), one of the major end products of lipid peroxidation, has been shown to induce apoptosis in a variety of cell lines. It appears to modulate signaling processes in more than one way because it has been suggested to
On the role of 4-hydroxynonenal in health and disease
Csala M, et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1852(5), 826-838 (2015)
Kamelija Zarkovic
Molecular aspects of medicine, 24(4-5), 293-303 (2003-08-02)
The development of oxidative stress, in which production of highly reactive oxygen species (ROS) overwhelms antioxidant defenses, is a feature of many neurological diseases: ischemic, inflammatory, metabolic and degenerative. Oxidative stress is increasingly implicated in a number of neurodegenerative disorders
Neven Zarkovic
Molecular aspects of medicine, 24(4-5), 281-291 (2003-08-02)
The review is focused on the currently major aspect of 4-hydroxynonenal (HNE) research--studies that combine biological activities of the aldehyde together with the methods of its identification in cells and tissues. Because there were some excellent reviews on HNE published
Yogesh C Awasthi et al.
Free radical biology & medicine, 37(5), 607-619 (2004-08-04)
4-Hydroxynonenal (HNE), one of the major end products of lipid peroxidation, has been shown to be involved in signal transduction and available evidence suggests that it can affect cell cycle events in a concentration-dependent manner. Glutathione S-transferases (GSTs) can modulate
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