870818M
Avanti
N-arachidonoylglycine
Avanti Research™ - A Croda Brand
别名:
methylene chloride solution
产品名称
N-arachidonoylglycine, methylene chloride solution, Avanti Research™ - A Croda Brand 870818M
方案
>99% (TLC)
表单
methylene chloride solution
包装
pkg of 1 × 1 mL (870818M-10mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 870818M
脂质类型
neutral glycerides
neutral lipids
运输
dry ice
储存温度
−20°C
SMILES字符串
O=C(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)NCC(O)=O
InChI
1S/C22H35NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21(24)23-20-22(25)26/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-20H2,1H3,(H,23,24)(H,25,26)/b7-6-,10-9-,13-12-,16-15-
InChI key
YLEARPUNMCCKMP-DOFZRALJSA-N
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一般描述
N-arachidonoylglycine (NAgly) is an endogenous ligand and a signaling lipid. It belongs to the eicosanoid family. NAgly is a natural ligand to activate G-protein coupled receptor, namely GPR18. It is found in rat brain and spinal cord.
生化/生理作用
N-arachidonoylglycine (NAgly) exhibits analgesic effects.
包装
2 mL Amber Glass Sealed Ampule (870818M-10mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
警示用语：
Warning
危险分类
Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Central nervous system
WGK
WGK 2
法规信息
危险化学品
此项目有
N-Amino acid linoleoyl conjugates: anti-inflammatory activities
Burstein S, et al.
Bioorganic & Medicinal Chemistry Letters, 22(2), 872-875 (2012)
Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18
Kohno M, et al.
Biochemical and Biophysical Research Communications, 347(3), 827-832 (2006)
T Sheskin et al.
Journal of medicinal chemistry, 40(5), 659-667 (1997-02-28)
In order to establish the structural requirements for binding to the brain cannabinoid receptor (CB1), we have synthesized numerous fatty acid amides, ethanolamides, and some related simple derivatives and have determined their Ki values. A few alpha-methyl- or alpha, alpha-dimethylarachidonoylalkylamides
S H Burstein et al.
Prostaglandins & other lipid mediators, 61(1-2), 29-41 (2000-04-29)
In addition to the well studied hydrolytic metabolism of anandamide, a number of oxidative processes are also possible. Several routes somewhat analogous to the metabolism of free arachidonic acid have been reported. These involve mediation by various lipoxygenases and COX-2
Resolution of inflammation by N-arachidonoylglycine
Burstein S H, et al.
Journal of Cellular Biochemistry, 112(11), 3227-3233 (2011)
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