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经验公式（希尔记法）:
C22H35NO3
化学文摘社编号:
分子量:
361.52
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
产品名称
N-arachidonoylglycine, methylene chloride solution, Avanti Research™ - A Croda Brand 870818M
SMILES string
O=C(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)NCC(O)=O
InChI
1S/C22H35NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21(24)23-20-22(25)26/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-20H2,1H3,(H,23,24)(H,25,26)/b7-6-,10-9-,13-12-,16-15-
InChI key
YLEARPUNMCCKMP-DOFZRALJSA-N
assay
>99% (TLC)
form
methylene chloride solution
packaging
pkg of 1 × 1 mL (870818M-10mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 870818M
lipid type
neutral glycerides
neutral lipids
shipped in
dry ice
storage temp.
−20°C
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General description
N-arachidonoylglycine (NAgly) is an endogenous ligand and a signaling lipid. It belongs to the eicosanoid family. NAgly is a natural ligand to activate G-protein coupled receptor, namely GPR18. It is found in rat brain and spinal cord.
Biochem/physiol Actions
N-arachidonoylglycine (NAgly) exhibits analgesic effects.
Packaging
2 mL Amber Glass Sealed Ampule (870818M-10mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
signalword
Warning
hcodes
Hazard Classifications
Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Central nervous system
wgk
WGK 2
法规信息
危险化学品
此项目有
N-Amino acid linoleoyl conjugates: anti-inflammatory activities
Burstein S, et al.
Bioorganic & Medicinal Chemistry Letters, 22(2), 872-875 (2012)
Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18
Kohno M, et al.
Biochemical and Biophysical Research Communications, 347(3), 827-832 (2006)
Resolution of inflammation by N-arachidonoylglycine
Burstein S H, et al.
Journal of Cellular Biochemistry, 112(11), 3227-3233 (2011)
S M Huang et al.
The Journal of biological chemistry, 276(46), 42639-42644 (2001-08-24)
In mammals, specific lipids and amino acids serve as crucial signaling molecules. In bacteria, conjugates of lipids and amino acids (referred to as lipoamino acids) have been identified and found to possess biological activity. Here, we report that mammals also
T Sheskin et al.
Journal of medicinal chemistry, 40(5), 659-667 (1997-02-28)
In order to establish the structural requirements for binding to the brain cannabinoid receptor (CB1), we have synthesized numerous fatty acid amides, ethanolamides, and some related simple derivatives and have determined their Ki values. A few alpha-methyl- or alpha, alpha-dimethylarachidonoylalkylamides
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