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Merck
CN

880622C

Avanti

16:0-02:0 PC

Avanti Research™ - A Croda Brand

别名:

1-palmitoyl-2-acetyl-sn-glycero-3-phosphocholine

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关于此项目

经验公式（希尔记法）:
C26H52NO8P
化学文摘社编号:
79512-78-0
分子量:
537.67
MDL number:
MFCD00798242
UNSPSC Code:
51191904
NACRES:
NA.25

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产品名称

16:0-02:0 PC, Avanti Research™ - A Croda Brand 880622C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(C)=O)COC(CCCCCCCCCCCCCCC)=O)=O

InChI

1S/C26H52NO8P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-26(29)32-22-25(35-24(2)28)23-34-36(30,31)33-21-20-27(3,4)5/h25H,6-23H2,1-5H3/t25-/m1/s1

InChI key

XPAXRSJGGFVTFM-RUZDIDTESA-N

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (880622C-5mg), pkg of 1 × 2.5 mL (880622C-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 880622C

concentration

10 mg/mL (880622C-25mg), 5 mg/mL (880622C-5mg)

lipid type

cardiolipins
phospholipids

shipped in

dry ice

storage temp.

−20°C

General description

Phosphocholine (PC) is an intermediate of phosphatidylcholine synthesis catalyzed by choline kinase. It is a phosphomonoester and contributes to the membrane phospholipids. 16:0-02:0 PC is an oxidized phospholipid and an analog of platelet activating factor (PAF).

Application

16:0-02:0 PC might be used in liposomes to study the hydrolyzing action of lysosomal phospholipase A2 (LPLA2) on truncated oxidized phosphatidylcholine in vitro.

Biochem/physiol Actions

16:0-02:0 PC acts as a receptor (PAF-R) agonist. Increase in the level of phosphocholine (PC) is observed in Alzheimer′s disease.

Packaging

5 mL Clear Glass Sealed Ampule (880622C-25mg)
5 mL Clear Glass Sealed Ampule (880622C-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

target_organs

Liver,Kidney, Respiratory system

存储类别

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

法规信息

易制毒化学品（2类）
危险化学品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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J W Geddes et al.
Neurobiology of aging, 18(3), 305-308 (1997-05-01)
At early stages of Alzheimer's disease, phosphomonoesters (PMEs) including phosphocholine (P-choline) are present at elevated levels. PMEs also are elevated in the developing brain during the period of neurite extension. To determine if the elevation of PMEs in AD could
Current Research in Alzheimer Therapy, 95-95 (1988)
Akira Abe et al.
Journal of lipid research, 58(2), 339-349 (2016-12-21)
Truncated oxidized glycerophospholipids (ox-PLs) are bioactive lipids resulting from oxidative stress. The catabolic pathways for truncated ox-PLs are not fully understood. Lysosomal phospholipase A2 (LPLA2) with phospholipase A and transacylase activities is a key enzyme in phospholipid homeostasis. The present
Alejandro Torrecillas et al.
International journal of pharmaceutics, 318(1-2), 28-40 (2006-04-21)
The effect of 1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphocholine (ET-18-OCH(3), edelfosine), and six other analog asymmetric phosholipids on the physical properties of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) model membranes was studied using differential scanning calorimetry (DSC), (31)P-nuclear magnetic resonance ((31)P NMR) and X-ray diffraction. DSC data revealed that
Valery Bochkov et al.
Free radical biology & medicine, 111, 6-24 (2016-12-29)
Oxidized phospholipids (OxPLs) are increasingly recognized to play a role in a variety of normal and pathological states. OxPLs were implicated in regulation of inflammation, thrombosis, angiogenesis, endothelial barrier function, immune tolerance and other important processes. Rapidly accumulating evidence suggests

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