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Merck
CN

890702C

Avanti

16:0 EPC (Cl Salt)

Avanti Research™ - A Croda Brand

别名:

1,2-dipalmitoyl-sn-glycero-3-ethylphosphocholine (chloride salt)

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关于此项目

经验公式（希尔记法）:
C42H85NO8PCl
化学文摘社编号:
328250-18-6
分子量:
798.55
UNSPSC代码:
12352211
NACRES:
NA.25

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产品名称

16:0 EPC (Cl Salt), Avanti Research™ - A Croda Brand 890702C

方案

>99% (TLC)

表单

liquid

包装

pkg of 1 × 1 mL (890702C-10mg)
pkg of 1 × 4 mL (890702C-100mg)

制造商/商品名称

Avanti Research™ - A Croda Brand 890702C

浓度

10 mg/mL (890702C-10mg)
25 mg/mL (890702C-100mg)

脂质类型

cationic lipids
transfection

运输

dry ice

储存温度

−20°C

SMILES字符串

O=P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)OCC.[Cl-]

一般描述

16:0 EPC or 1,2-dipalmitoyl-sn-glycero-3-ethylphosphocholine is a P-O-ethyl derivative and a saturated cationic lipid.

应用

1,2-dipalmitoyl-sn-glycero-3-ethylphosphocholine (16:0 EPC (Cl Salt)):
  • has been used to design lipid nanoparticles of lower transition temperature, to enhance intracellular delivery mediated by shock waves
  • is suitable for use as a cationic lipid to examine its miscibility and phase behavior with zwitterionic lipids
  • may be used in liposome preparation

生化/生理作用

Cationic lipids serve as a DNA and RNA transfecting agent. They behave as co-adjuvants for preparing vaccines and promote drug delivery. Ethyl phosphocholine (EPC) lipids resemble the cellular lipids, hence they are less toxic. They are also found to be metabolized by cells, as a result, they act as a potential non-viral transfection agent.

包装

5 mL Clear Glass Sealed Ampule (890702C-100mg)
5 mL Clear Glass Sealed Ampule (890702C-10mg)

法律信息

Avanti Research is a trademark of Avanti Polar Lipids, LLC

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

靶器官

Liver,Kidney, Respiratory system

储存分类代码

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

闪点(°F)

does not flash

闪点(°C)

does not flash

法规信息

易制毒化学品（2类）
危险化学品
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分析证书(COA)

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Eric A Smith et al.
Biophysical chemistry, 196, 86-91 (2014-12-03)
To examine the phase behavior of mixtures of zwitterionic and cationic lipids we used three derivatives of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC). All three lipids are uniquely capable of spontaneously forming the interdigitated gel phase (LβI) under typical hydration conditions. The P-O-ethyl derivative
Costanza Montis et al.
Soft matter, 10(24), 4287-4297 (2014-05-03)
Ethylphosphocholine lipids are highly biocompatible cationic amphiphiles that can be used for the formulation of liposomal DNA vectors, with negligible toxic effects on cells and organisms. Here we report the characterization of EDPPC (1,2-dipalmitoyl-sn-glycero-O-ethyl-3-phosphocholine chloride) liposomes, containing two different zwitterionic
Eric A Smith et al.
Biophysical chemistry, 190-191, 1-7 (2014-04-22)
The effects of adding cis- and trans-unsaturated lipid to a fully interdigitated membrane were examined using differential scanning calorimetry (DSC) and X-ray diffraction. A monofluorinated analog of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) was used as the interdigitated lipid. The single fluorine atom on
Jing Zhang et al.
ACS applied materials & interfaces, 11(11), 10481-10491 (2019-02-23)
Cellular membranes are, in general, impermeable to macromolecules (herein referred to as macrodrugs, e.g., recombinant protein, expression plasmids, or mRNA), which is a major barrier for clinical translation of macrodrug-based therapies. Encapsulation of macromolecules in lipid nanoparticles (LNPs) can protect
Chu Wang et al.
Langmuir : the ACS journal of surfaces and colloids, 36(6), 1615-1622 (2020-01-23)
Body fluids flow all over the body and affect the biological processes at biointerfaces. To simulate such a case, sum frequency generation (SFG) vibrational spectroscopy and a self-designed microfluidic chip were combined together to investigate the interaction between a pH-responsive
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