产品名称
16:0 EPC (Cl Salt), Avanti Research™ - A Croda Brand 890702C
SMILES string
O=P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)OCC.[Cl-]
assay
>99% (TLC)
form
liquid
packaging
pkg of 1 × 1 mL (890702C-10mg), pkg of 1 × 4 mL (890702C-100mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 890702C
concentration
10 mg/mL (890702C-10mg), 25 mg/mL (890702C-100mg)
lipid type
cationic lipids
transfection
shipped in
dry ice
storage temp.
−20°C
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General description
16:0 EPC or 1,2-dipalmitoyl-sn-glycero-3-ethylphosphocholine is a P-O-ethyl derivative and a saturated cationic lipid.
Application
1,2-dipalmitoyl-sn-glycero-3-ethylphosphocholine (16:0 EPC (Cl Salt)):
- has been used to design lipid nanoparticles of lower transition temperature, to enhance intracellular delivery mediated by shock waves
- is suitable for use as a cationic lipid to examine its miscibility and phase behavior with zwitterionic lipids
- may be used in liposome preparation
Biochem/physiol Actions
Cationic lipids serve as a DNA and RNA transfecting agent. They behave as co-adjuvants for preparing vaccines and promote drug delivery. Ethyl phosphocholine (EPC) lipids resemble the cellular lipids, hence they are less toxic. They are also found to be metabolized by cells, as a result, they act as a potential non-viral transfection agent.
Packaging
5 mL Clear Glass Sealed Ampule (890702C-100mg)
5 mL Clear Glass Sealed Ampule (890702C-10mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
signalword
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3
target_organs
Liver,Kidney, Respiratory system
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
does not flash
flash_point_c
does not flash
法规信息
易制毒化学品（2类）
危险化学品
此项目有
Eric A Smith et al.
Biophysical chemistry, 196, 86-91 (2014-12-03)
To examine the phase behavior of mixtures of zwitterionic and cationic lipids we used three derivatives of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC). All three lipids are uniquely capable of spontaneously forming the interdigitated gel phase (LβI) under typical hydration conditions. The P-O-ethyl derivative
Costanza Montis et al.
Soft matter, 10(24), 4287-4297 (2014-05-03)
Ethylphosphocholine lipids are highly biocompatible cationic amphiphiles that can be used for the formulation of liposomal DNA vectors, with negligible toxic effects on cells and organisms. Here we report the characterization of EDPPC (1,2-dipalmitoyl-sn-glycero-O-ethyl-3-phosphocholine chloride) liposomes, containing two different zwitterionic
Eric A Smith et al.
Biophysical chemistry, 190-191, 1-7 (2014-04-22)
The effects of adding cis- and trans-unsaturated lipid to a fully interdigitated membrane were examined using differential scanning calorimetry (DSC) and X-ray diffraction. A monofluorinated analog of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) was used as the interdigitated lipid. The single fluorine atom on
Jing Zhang et al.
ACS applied materials & interfaces, 11(11), 10481-10491 (2019-02-23)
Cellular membranes are, in general, impermeable to macromolecules (herein referred to as macrodrugs, e.g., recombinant protein, expression plasmids, or mRNA), which is a major barrier for clinical translation of macrodrug-based therapies. Encapsulation of macromolecules in lipid nanoparticles (LNPs) can protect
Chu Wang et al.
Langmuir : the ACS journal of surfaces and colloids, 36(6), 1615-1622 (2020-01-23)
Body fluids flow all over the body and affect the biological processes at biointerfaces. To simulate such a case, sum frequency generation (SFG) vibrational spectroscopy and a self-designed microfluidic chip were combined together to investigate the interaction between a pH-responsive
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